Technology Process of 3,4,6-tri-O-(triisopropylsilyl)-D-galactal
There total 1 articles about 3,4,6-tri-O-(triisopropylsilyl)-D-galactal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
2,6-dimethylpyridine;
In
N,N-dimethyl-formamide;
at 0 - 60 ℃;
for 48h;
Inert atmosphere;
DOI:10.1021/acs.orglett.7b01583
- Guidance literature:
-
3,4,6-tri-O-(triisopropylsilyl)-D-galactal;
With
tert.-butyl lithium;
In
tetrahydrofuran; pentane;
at -78 - 0 ℃;
Inert atmosphere;
iodobenzene;
With
indium(III) chloride;
In
tetrahydrofuran; pentane;
at -78 - 20 ℃;
Inert atmosphere;
With
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; pentane;
at 70 ℃;
for 20h;
Inert atmosphere;
DOI:10.1021/ja8052706
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.5 h / -78 - 0 °C / Inert atmosphere
1.2: 3 h / -78 °C / Inert atmosphere
2.1: palladium diacetate; sodium hydrogencarbonate; 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate; oxygen / tert-Amyl alcohol; water / 14 h / 100 °C / 760.05 Torr / Schlenk technique; Green chemistry
With
tert.-butyl lithium; oxygen; palladium diacetate; sodium hydrogencarbonate; 1-tert-butyl 2-methyl (2S,4R)-4-hydroxy-1,2-pyrrolidinedicarboxylate;
In
tetrahydrofuran; tert-Amyl alcohol; water; pentane;
DOI:10.1021/acs.orglett.6b00566
