carbocyclic 5'-nor-2'-deoxyguanosine

Base Information

Chemical Name:carbocyclic 5'-nor-2'-deoxyguanosine
CAS No.:140438-62-6
Molecular Formula:C₁₀H₁₃N₅O₃
Molecular Weight:251.245
Hs Code.:
Mol file:140438-62-6.mol

Synonyms:6H-Purin-6-one,2-amino-1,9-dihydro-9-(3,4-dihydroxycyclopentyl)-, (1a,3a,4b)- (9CI); 6H-Purin-6-one,2-amino-1,9-dihydro-9-(3,4-dihydroxycyclopentyl)-, (1a,3a,4b)-(?à)-

Suppliers and Price of carbocyclic 5'-nor-2'-deoxyguanosine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of carbocyclic 5'-nor-2'-deoxyguanosine

Chemical Property:

Boiling Point:627.8oC at 760 mmHg
Flash Point:333.5oC
PSA：131.04000
Density:2.06g/cm3
LogP:-0.89910

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of carbocyclic 5'-nor-2'-deoxyguanosine

There total 9 articles about carbocyclic 5'-nor-2'-deoxyguanosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 140438-67-1
(+/-)-(1α,2β,4β)-4-(2-amino-6-chloro-9H-purin-9-yl)-1,2-cyclopentanediol

: 140438-62-6
(+/-)-2-amino-1,9-dihydro-9-<(1'α,3'β,4'β)-(3',4'dihydroxy-1'cyclopentyl)>-6H-purin-6-one

Guidance literature:: With hydrogenchloride; In water; for 5h; Heating;
DOI:10.1021/jm00090a007

Reference yield:

: (+/-)-(1α,2β,4β)-4-amino-1,2-cyclopentanediol

: 140438-62-6
(+/-)-2-amino-1,9-dihydro-9-<(1'α,3'β,4'β)-(3',4'dihydroxy-1'cyclopentyl)>-6H-purin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: Et₃N / butan-1-ol / 48 h / Heating

2: 75.5 percent / AcONa*3H₂O, glacial AcOH / H₂O / Ambient temperature

3: 65 percent / Zn, AcOH / ethanol; H₂O / 5 h / 80 - 85 °C

4: 2.) 0.5N HCl / 1.) 80 deg C, 20 h, 2.) H₂O, RT, 30 min

5: 75 percent / 1N HCl / H₂O / 5 h / Heating

With hydrogenchloride; sodium acetate; acetic acid; triethylamine; zinc; In ethanol; water; butan-1-ol;
DOI:10.1021/jm00090a007

Reference yield:

: 132065-12-4
4-benzamidocyclopentene

: 140438-62-6
(+/-)-2-amino-1,9-dihydro-9-<(1'α,3'β,4'β)-(3',4'dihydroxy-1'cyclopentyl)>-6H-purin-6-one

Guidance literature:: Multi-step reaction with 9 steps

1: 96 percent / MCPBA / CHCl₃ / 1 h / Ambient temperature

2: 2percent aq.H₂SO₄ / 1 h / Ambient temperature

3: pyridine / Ambient temperature

4: 6N HCl / H₂O / 24 h / Heating

5: Et₃N / butan-1-ol / 48 h / Heating

6: 75.5 percent / AcONa*3H₂O, glacial AcOH / H₂O / Ambient temperature

7: 65 percent / Zn, AcOH / ethanol; H₂O / 5 h / 80 - 85 °C

8: 2.) 0.5N HCl / 1.) 80 deg C, 20 h, 2.) H₂O, RT, 30 min

9: 75 percent / 1N HCl / H₂O / 5 h / Heating

With pyridine; hydrogenchloride; sulfuric acid; sodium acetate; acetic acid; triethylamine; 3-chloro-benzenecarboperoxoic acid; zinc; In ethanol; chloroform; water; butan-1-ol;
DOI:10.1021/jm00090a007