N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine

Base Information

• Chemical Name: N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine
• CAS No.: 1258064-80-0
• Molecular Formula: C₂₄H₂₃NO₂S
• Molecular Weight: 389.518
• Mol file: 1258064-80-0.mol

Synonyms:N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine

Chemical Property of N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine

There total 3 articles about N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

N-benzyl-p-toluenesulfonamide (1576-37-0) + (2,2-dibromoethenyl)-2,6-dimethylbenzene (1391469-79-6) → N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine (1258064-80-0)

Guidance literature:

With copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine; Heating;

DOI:10.1021/om3005614

Reference yield: 36.0%

2,6-dimethyliodobenzene (608-28-6) + N-benzyl-N-ethynyl-4-methyl-benzenesulfonamide (205885-39-8) → N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine (1258064-80-0)

Guidance literature:

With sodium acetate; palladium diacetate; triphenylphosphine; In N,N-dimethyl-formamide; at 0 - 80 ℃; Inert atmosphere;

DOI:10.1055/s-0030-1258023

Reference yield:

2,6-dimethylbenzaldehyde (1123-56-4) → N-benzyl-N-4-toluenesulfonyl-(2,6-dimethylphenyl)ethynylamine (1258064-80-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: triphenylphosphine / dichloromethane / 1 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 24 h / 70 °C / Inert atmosphere

With copper(l) iodide; caesium carbonate; triphenylphosphine; N,N`-dimethylethylenediamine; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ja504818p

upstream raw materials:

2,6-dimethyliodobenzene

N-benzyl-N-ethynyl-4-methyl-benzenesulfonamide

N-benzyl-p-toluenesulfonamide

(2,2-dibromoethenyl)-2,6-dimethylbenzene