2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt
CAS No.:1283142-41-5
Molecular Formula:C₂HF₃O₂*C₂₀H₂₃NO₃
Molecular Weight:439.431
Hs Code.:

Synonyms:2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Chemical Property of 2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

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Technology Process of 2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

There total 8 articles about 2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.8%

: 1283145-86-7
2-((2S,4R)-4-(benzyloxy)-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

: 1283142-41-5
2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

: 40350-83-2,54631-82-2,54631-81-1
(2S,4R)-4-(benzyloxy)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid

: 1283142-41-5
2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / -10 °C

1.2: 0.5 h / 0 °C

2.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

3.1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 12 h / 90 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 0 °C

5.1: dimethyl sulfoxide / 4 h / 50 °C

6.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 100 °C / Ineryt atmosphere

7.1: water; potassium hydroxide / ethanol / 100 °C

7.2: pH ~ 2 - ~ 3

8.1: hydrogen / palladium on activated charcoal / methanol

With 4-methyl-morpholine; hydrogenchloride; water; hydrogen; triethylamine; potassium hydroxide; sodium hydroxide; isobutyl chloroformate; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 109953-95-9
tert-butyl (2S,4R)-4-(benzyloxy)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

: 1283142-41-5
2-((2S,4R)-4-hydroxy-1-(4-(2-methylbenzyl)phenyl)pyrrolidin-2-yl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 1,4-dioxane / 0.5 h / 20 °C

2.1: sodium hydroxide / copper(l) iodide / isopropyl alcohol / 12 h / 90 °C / Inert atmosphere

3.1: triethylamine / dichloromethane / 1 h / 0 °C

4.1: dimethyl sulfoxide / 4 h / 50 °C

5.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 1 h / 100 °C / Ineryt atmosphere

6.1: water; potassium hydroxide / ethanol / 100 °C

6.2: pH ~ 2 - ~ 3

7.1: hydrogen / palladium on activated charcoal / methanol

With hydrogenchloride; water; hydrogen; triethylamine; potassium hydroxide; sodium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide; isopropyl alcohol;