(-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

Base Information

Chemical Name:(-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane
CAS No.:1318231-03-6
Molecular Formula:C₂₁H₃₆O₃Si
Molecular Weight:364.601
Hs Code.:

Synonyms:(-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

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Chemical Property of (-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

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Technology Process of (-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

There total 4 articles about (-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 3587-60-8
Benzyloxymethyl chloride

: 1318231-01-4
(-)-(3S,4S)-4-((tert-butyldimethylsilyl)oxy)-2-methylhex-5-en-3-ol

: 1318231-03-6
(-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

Guidance literature:: With tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/ja206013j

Reference yield:

: 1318230-47-5
(-)-(R)-2-((2-methylhex-5-en-3-yl)oxy)acetic acid

: 1318231-03-6
(-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C / pH 4 / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: samarium diiodide; ethylene glycol / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 12 h / 20 °C / Inert atmosphere

3.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With samarium diiodide; tetra-(n-butyl)ammonium iodide; ethylene glycol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;
DOI:10.1021/ja206013j

Reference yield:

: 88691-75-2
(3R)-2-methyl-hex-5-en-3-ol

: 1318231-03-6
(-)-(5S,6S)-5-isopropyl-8,8,9,9-tetramethyl-1-phenyl-6-vinyl-2,4,7-trioxa-8-siladecane

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: lithium hydroxide / tetrahydrofuran; water / 0.5 h / 0 °C / pH 4 / Inert atmosphere

2.2: 0 °C / Inert atmosphere

3.1: samarium diiodide; ethylene glycol / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 12 h / 20 °C / Inert atmosphere

4.1: tetra-(n-butyl)ammonium iodide; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With samarium diiodide; tetra-(n-butyl)ammonium iodide; sodium hydride; ethylene glycol; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; dichloromethane; water;
DOI:10.1021/ja206013j