N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide

Base Information

• Chemical Name: N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide
• CAS No.: 104448-46-6
• Molecular Formula: C₃₁H₃₅N₃O₅S
• Molecular Weight: 561.702

Synonyms:N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide

Chemical Property of N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide

Chemical Property:

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Technology Process of N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide

There total 4 articles about N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

benzenesulfonamide (98-10-2) + 4-[6-(2-ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoic acid (104436-22-8) → N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide (104448-46-6)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; for 18.25h;

DOI:10.1021/jm00171a018

Reference yield:

4-[6-(2-ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoic acid (104436-22-8) → N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide (104448-46-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / Et₃N / methanol

2: 1.) NaH / 1.) DMF, 1 h, 2.) 1 h

With sodium hydride; triethylamine; In methanol;

DOI:10.1021/jm00171a018

Reference yield:

benzenesulfonamide (98-10-2) + 4-<<6-(2-ethylhexanamido)indol-1-yl>methyl>-3-methoxybenzoic N,N-diphenylcarbamic anhydride (104448-45-5) → N-(4-[6-(2 ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoyl)benzenesulphonamide (104448-46-6)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) DMF, 1 h, 2.) 1 h;

DOI:10.1021/jm00171a018

upstream raw materials:

benzenesulfonamide

4-[6-(2-ethylhexanamido)indol-1-ylmethyl]-3-methoxybenzoic acid

4-<<6-(2-ethylhexanamido)indol-1-yl>methyl>-3-methoxybenzoic N,N-diphenylcarbamic anhydride

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