N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide
CAS No.:1333467-15-4
Molecular Formula:C₂₆H₂₉NO₄S
Molecular Weight:451.587
Hs Code.:

Synonyms:N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

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Chemical Property of N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

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Technology Process of N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

There total 2 articles about N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1333467-27-8
1-[(benzyloxy)methyl]cyclobutane-1-carbaldehyde

: 18773-54-1
4-methyl-N,N-diprop-2-ynylbenzenesulfonamide

: 1333467-15-4
N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

Guidance literature:: 4-methyl-N,N-diprop-2-ynylbenzenesulfonamide; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h; Inert atmosphere;

1-[(benzyloxy)methyl]cyclobutane-1-carbaldehyde; In tetrahydrofuran; at -78 ℃; for 0.0833333h; Inert atmosphere;
DOI:10.1002/chem.201101441

Reference yield:

: 568591-39-9
{1-[(benzyloxy)methyl]cyclobutyl}methanol

: 1333467-15-4
N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; dimethyl sulfoxide / 2 h / 20 °C / Inert atmosphere

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.08 h / -78 °C / Inert atmosphere

With lithium hexamethyldisilazane; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1002/chem.201101441

Reference yield:

: 1333467-15-4
N-{4-(1-benzyloxymethylcyclobutyl)-4-hydroxy-2-butynyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

: 1333466-99-1
N-{4-(1-benzyloxymethylcyclobutyl)-2-phenylsulfonyl-2,3-butadienyl}-N-(2-propynyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / tetrahydrofuran / -78 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.5 h / 0 °C / Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1002/chem.201101441