Technology Process of trans-4-aminocyclohexyl benzoate
There total 3 articles about trans-4-aminocyclohexyl benzoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
trans-4-azidocyclohexyl benzoate;
With
9-phenyl-9-phosphafluorene; phenylsilane;
In
1,4-dioxane;
at 101 ℃;
for 16h;
Inert atmosphere;
With
water;
In
1,4-dioxane;
at 20 ℃;
Inert atmosphere;
DOI:10.1002/adsc.201100967
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: pyridine; dmap; triethylamine / dichloromethane / 0 °C
2.1: 9-phenyl-9-phosphafluorene; phenylsilane / 1,4-dioxane / 16 h / 101 °C / Inert atmosphere
2.2: 20 °C / Inert atmosphere
With
pyridine; dmap; 9-phenyl-9-phosphafluorene; phenylsilane; triethylamine;
In
1,4-dioxane; dichloromethane;
2.1: Staudinger reduction reaction / 2.2: Staudinger reduction reaction;
DOI:10.1002/adsc.201100967
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; potassium carbonate / methanol / 16 h / 20 °C
2.1: pyridine; dmap; triethylamine / dichloromethane / 0 °C
3.1: 9-phenyl-9-phosphafluorene; phenylsilane / 1,4-dioxane / 16 h / 101 °C / Inert atmosphere
3.2: 20 °C / Inert atmosphere
With
pyridine; dmap; imidazole-1-sulfonyl azide hydrochloride; copper(ll) sulfate pentahydrate; 9-phenyl-9-phosphafluorene; phenylsilane; potassium carbonate; triethylamine;
In
1,4-dioxane; methanol; dichloromethane;
3.1: Staudinger reduction reaction / 3.2: Staudinger reduction reaction;
DOI:10.1002/adsc.201100967
