methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate

Base Information

• Chemical Name: methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate
• CAS No.: 1607495-19-1
• Molecular Formula: C₁₄H₁₂F₃NO₃S
• Molecular Weight: 331.315
• Mol file: 1607495-19-1.mol

Synonyms:methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate

Chemical Property of methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate

There total 3 articles about methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(methylthio)-1-phenyl-5-(trifluoromethyl)-1H-pyrrole-3-carboxylate (1607495-17-9) → methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate (1607495-19-1)

Guidance literature:

With dihydrogen peroxide; In water; phenol; at 50 ℃; for 5h;

DOI:10.1021/jo500534t

Reference yield:

methyl 2-(trifluoromethyl)-2-[(trimethylsilyl)oxy]cyclopropanecarboxylate → methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate (1607495-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 5 h / -78 - 21 °C

2.1: dihydrogen peroxide / phenol; water / 5 h / 50 °C

With dihydrogen peroxide; lithium diisopropyl amide; In tetrahydrofuran; water; phenol;

DOI:10.1021/jo500534t

Reference yield:

phenyl isothiocyanate (103-72-0) → methyl 2-(methylsulfinyl)-1-phenyl-5-(trifluoromethyl)-1Hpyrrole-3-carboxylate (1607495-19-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 2 h / -78 °C

1.2: 5 h / -78 - 21 °C

2.1: dihydrogen peroxide / phenol; water / 5 h / 50 °C

With dihydrogen peroxide; lithium diisopropyl amide; In tetrahydrofuran; water; phenol;

DOI:10.1021/jo500534t

upstream raw materials:

methyl 2-(methylthio)-1-phenyl-5-(trifluoromethyl)-1H-pyrrole-3-carboxylate

phenyl isothiocyanate

Downstream raw materials:

methyl 1-phenyl-5-(trifluoromethyl)-1H-pyrrole-3-carboxylate