3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

Base Information

Chemical Name:3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate
CAS No.:1356032-70-6
Molecular Formula:C₂₂H₂₂Cl₃F₂NO₄
Molecular Weight:508.777
Hs Code.:

Synonyms:3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

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Chemical Property of 3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

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Technology Process of 3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

There total 1 articles about 3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-D-galactopyranose

: 545-06-2
trichloroacetonitrile

: 1356032-70-6
3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1039/c1cc15139h

Reference yield: 69.0%

: 1356032-70-6
3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

: C₄₂H₄₉NO₉

: N-(benzyl)benzyloxycarbonyl-5-aminopentyl 3,4-di-O-benzyl-2,6-dideoxy-2,6-difluoro-β-D-galactopyranosyl-(1→4)-2-O-acetyl-3,6-di-O-benzyl-α-D-mannopyranoside

Guidance literature:: With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; acetonitrile; at -78 ℃; for 0.5h; Inert atmosphere; Molecular sieve;
DOI:10.1002/ejoc.201800384

Reference yield:

: 1191118-09-8
N-(9H-fluoren-9-yl)-methoxycarbonyl-O-(2-acetamido-2,6-dideoxy-6-fluoro-α-D-galactopyranosyl)-L-threonine tert-butyl ester

: 1356032-70-6
3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate

: 1356032-71-7
N-(9H-fluoren-9-yl)-methoxycarbonyl-O-(2-acetamido-2,6-dideoxy-6-fluoro-3-O-[3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-β-D-galactopyranosyl]-α-D-galactopyranosyl)-L-threonine tert-butyl ester

: N-(9H-fluoren-9-yl)-methoxycarbonyl-O-(2-acetamido-2,6-dideoxy-6-fluoro-3-O-[3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl]-α-D-galactopyranosyl)-L-threonine tert-butyl ester

Guidance literature:: N-(9H-fluoren-9-yl)-methoxycarbonyl-O-(2-acetamido-2,6-dideoxy-6-fluoro-α-D-galactopyranosyl)-L-threonine tert-butyl ester; 3,4-di-O-benzyl-2,6-dideoxy-2,6-fluoro-α-D-galactopyranosyl trichloroacetimidate; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere; Molecular sieve;

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -10 - 20 ℃; for 20h; optical yield given as %de; stereoselective reaction; Inert atmosphere; Molecular sieve;
DOI:10.1039/c1cc15139h