Quinidine sulfate dihydrate

Base Information

• Chemical Name: Quinidine sulfate dihydrate
• CAS No.: 6591-63-5
• Deprecated CAS: 60553-86-8
• Molecular Formula: 2C₂₀H₂₄N₂O₂*8H₂O*H₂O₄S
• Molecular Weight: 891.047
• Hs Code.: 2939200050
• European Community (EC) Number: 200-046-3,678-472-8
• UNII: J13S2394HE
• DSSTox Substance ID: DTXSID101017271
• Wikidata: Q27281012
• NCI Thesaurus Code: C48014
• RXCUI: 9069
• Pharos Ligand ID: FVG9PYTL7D4N
• ChEMBL ID: CHEMBL3707183
• Mol file: 6591-63-5.mol

Synonyms:(S)-[(4S,5R,7R)-5-Ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol sulfate dihydrate

Chemical Property of Quinidine sulfate dihydrate

Chemical Property:

• Appearance/Colour: white to light yellow crystal powde
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 212-214 ºC (dec.)
• Refractive Index: 275 ° (C=2, 0.1mol/L HCl)
• Boiling Point: 992.5°C at 760 mmHg
• Flash Point: 554°C
• PSA: 192.62000
• LogP: 6.52160
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive.: Light Sensitive
• Solubility.: Slightly soluble in water, soluble in boiling water and in ethanol (96 per cent), practically insoluble in acetone.
• Water Solubility.: Soluble in chloroform, water (11 mg/ml at 20°C), alcohol, and ethanol (50 mg/ml).
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 14
• Rotatable Bond Count: 8
• Exact Mass: 782.35606511
• Heavy Atom Count: 55
• Complexity: 538

Purity/Quality:

98%,99%, ^*data from raw suppliers

Quinidine Sulfate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-20/21/22
• Safety Statements: 13-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.COC1=CC2=C(C=CN=C2C=C1)C(C3CC4CCN3CC4C=C)O.O.O.OS(=O)(=O)O
• Isomeric SMILES: COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.COC1=CC2=C(C=CN=C2C=C1)[C@@H]([C@H]3C[C@@H]4CCN3C[C@@H]4C=C)O.O.O.OS(=O)(=O)O
• Recent ClinicalTrials: Study of the Electrocardiographic Effects of Ranolazine, Dofetilide, Verapamil, and Quinidine in Healthy Subjects
• Recent NIPH Clinical Trials: Quinidine sulfate administration for intractable epilepsy with KCNT1 gene mutation
• Uses: Quinidine sulfate dihydrate (cas# 6591-63-5) is the hydrated, sulfate salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.
• Clinical Use: Quinidine sulfate is the prototype of antiarrhythmicdrugs and a class IA antiarrhythmic agent according to theVaughan Williams classification. It reduces Na+ current bybinding the open ion channels (i.e., state A). The decreasedNa+entry into the myocardial cell depresses phase 4 diastolicdepolarization and shifts the intracellular threshold potentialtoward zero. These combined actions diminish thespontaneous frequency of pacemaker tissues, depress theautomaticity of ectopic foci, and, to a lesser extent, reduceimpulse formation in the SA node. This last action results inbradycardia. During the spike action potential, quinidinesulfate decreases transmembrane permeability to passiveinflux of Na+, thus slowing the process of phase 0 depolarization,which decreases conduction velocity. This is shownas a prolongation of the QRS complex of electrocardiograms.Quinidine sulfate also prolongs action potential duration,which results in a proportionate increase in the QTinterval. It is used to treat supraventricular and ventricularectopic arrhythmias, such as atrial and ventricular prematurebeats, atrial and ventricular tachycardia, atrial flutter, andatrial fibrillation.

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