methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

Base Information

Chemical Name:methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate
CAS No.:1422387-43-6
Molecular Formula:C₂₆H₃₉N₅O₇Si
Molecular Weight:561.71
Hs Code.:

Synonyms:methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

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Chemical Property of methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

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Technology Process of methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

There total 1 articles about methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 1422387-42-5
methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1H-imidazol-5-yl)-3-nitrophenyl)carbamate

: 76513-69-4
(2-trimethylethylsilylethoxy)methyl chloride

: 1422387-43-6
methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

Guidance literature:: methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1H-imidazol-5-yl)-3-nitrophenyl)carbamate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

(2-trimethylethylsilylethoxy)methyl chloride; In tetrahydrofuran; at 0 ℃; for 1h;

Reference yield: 77.0%

: 1422387-43-6
methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

: 1329167-30-7
tert-butyl N-[(1S)-1-(4-{2-amino-4-[(methoxycarbonyl)-amino]phenyl}-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-imidazol-2-yl)but-3-en-1-yl]carbamate

Guidance literature:: With ammonium chloride; zinc; In methanol; at 60 ℃; for 4h; Sealed tube;

Reference yield:

: 1422387-43-6
methyl N-(4-(2-((1S)-1-((tert-butoxycarbonyl)amino)but-3-en-1-yl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-4-yl)-3-nitrophenyl)carbamate

: 1329169-69-8
(6S)-6-((tert-butoxycarbonyl)amino)-6-(4-(4-((methoxycarbonyl)amino)-2-(2,2,2-trifluoroacetamido)phenyl)-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazol-2-yl)-2-methylhexanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc; ammonium chloride / methanol / 4 h / 60 °C / Sealed tube

2.1: triethylamine / ethyl acetate / 0.5 h / 0 °C / Inert atmosphere

3.1: toluene-4-sulfonic acid / dichloromethane / 0.67 h / 40 °C / Inert atmosphere

3.2: 40 °C / Inert atmosphere

4.1: hydrogen; palladium on activated charcoal / methanol / 20 °C / Inert atmosphere

With palladium on activated charcoal; hydrogen; ammonium chloride; toluene-4-sulfonic acid; triethylamine; zinc; In methanol; dichloromethane; ethyl acetate;