methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

Base Information

Chemical Name:methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate
CAS No.:1432503-86-0
Molecular Formula:C₂₂H₂₅BrFN₃O₅S
Molecular Weight:542.426
Hs Code.:

Synonyms:methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

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Chemical Property of methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

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Technology Process of methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

There total 9 articles about methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1432503-79-1
methyl 2-(7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

: 76283-09-5
4-bromo-2-fluorobenzyl bromide

: 1432503-86-0
methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

Guidance literature:: With potassium carbonate; In acetonitrile; at 70 ℃; for 2h;
DOI:10.1002/cmdc.201200386

Reference yield:

: 106-49-0,12221-03-3
p-toluidine

: 1432503-86-0
methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

Guidance literature:: Multi-step reaction with 9 steps

1.1: nitromethane / 0.5 h / -40 °C

1.2: 1 h / 110 °C

2.1: sodium hydroxide; potassium permanganate / water / 7 h / 0 - 80 °C

2.2: pH 1

3.1: sulfuric acid / water / 6 h / 140 °C

3.2: 0.5 h / 0 °C

4.1: 2 h / Reflux

5.1: thionyl chloride / 75 °C

6.1: triethylamine / acetonitrile / 0.5 h / 20 °C

7.1: potassium carbonate / acetonitrile / 2 h / 75 °C

8.1: sodium tetrahydroborate / methanol / 0.08 h

9.1: potassium carbonate / acetonitrile / 2 h / 70 °C

With sodium tetrahydroborate; potassium permanganate; thionyl chloride; sulfuric acid; potassium carbonate; triethylamine; sodium hydroxide; In methanol; nitromethane; water; acetonitrile;
DOI:10.1002/cmdc.201200386

Reference yield:

: 201224-76-2
3-oxo-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine-7-carboxylic acid 1,1-dioxide

: 1432503-86-0
methyl 2-(2-(4-bromo-2-fluorobenzyl)-7-(diethylcarbamoyl)-1,1-dioxo-2H-benzo[e][1,2,4]thiadiazin-4(3H)-yl)acetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / water / 6 h / 140 °C

1.2: 0.5 h / 0 °C

2.1: 2 h / Reflux

3.1: thionyl chloride / 75 °C

4.1: triethylamine / acetonitrile / 0.5 h / 20 °C

5.1: potassium carbonate / acetonitrile / 2 h / 75 °C

6.1: sodium tetrahydroborate / methanol / 0.08 h

7.1: potassium carbonate / acetonitrile / 2 h / 70 °C

With sodium tetrahydroborate; thionyl chloride; sulfuric acid; potassium carbonate; triethylamine; In methanol; water; acetonitrile;
DOI:10.1002/cmdc.201200386