MCJ₀₀₁F-RR

Base Information

• Chemical Name: MCJ₀₀₁F-RR
• CAS No.: 1172112-42-3
• Molecular Formula: C₂₀H₂₀FN
• Molecular Weight: 293.384
• Mol file: 1172112-42-3.mol

Synonyms:MCJ₀₀₁F-RR

Chemical Property of MCJ₀₀₁F-RR

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of MCJ₀₀₁F-RR

There total 5 articles about MCJ₀₀₁F-RR which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-cyano-N-((2R,3R)-3-fluoro-2-(naphthalen-2-yl)-3-phenylpropyl)-N-methylbenzenesulfonamide → MCJ001F-RR (1172112-42-3)

Guidance literature:

4-cyano-N-((2R,3R)-3-fluoro-2-(naphthalen-2-yl)-3-phenylpropyl)-N-methylbenzenesulfonamide; With 1-dodecylthiol; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.1c03178

Reference yield:

4-cyano-N-(3-(2-formylphenyl)prop-2-yn-1-yl)-N-methylbenzenesulfonamide → MCJ001F-RR (1172112-42-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine; hydrogen / 72 h / 20 °C

2.1: 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); silver fluoride; water; (S)-2-amino-1-(4,4-dimethylpiperidin-1-yl)-3,3-dimethylbutan-1-one / dichloromethane; acetonitrile / 72 h / 35 °C / Inert atmosphere

3.1: Wilkinson's catalyst / m-xylene / 16 h / 140 °C / Inert atmosphere

4.1: 1-dodecylthiol / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

4.2: 12 h / 20 °C / Inert atmosphere

With pyridine; tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); Wilkinson's catalyst; 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; water; hydrogen; silver fluoride; (S)-2-amino-1-(4,4-dimethylpiperidin-1-yl)-3,3-dimethylbutan-1-one; 1-dodecylthiol; In dichloromethane; N,N-dimethyl-formamide; m-xylene; acetonitrile;

DOI:10.1021/jacs.1c03178

Reference yield:

2-iodobenzaldehyde (26260-02-6) → MCJ001F-RR (1172112-42-3)

Guidance literature:

Multi-step reaction with 5 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / 0.17 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: pyridine; hydrogen / 72 h / 20 °C

3.1: 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); silver fluoride; water; (S)-2-amino-1-(4,4-dimethylpiperidin-1-yl)-3,3-dimethylbutan-1-one / dichloromethane; acetonitrile / 72 h / 35 °C / Inert atmosphere

4.1: Wilkinson's catalyst / m-xylene / 16 h / 140 °C / Inert atmosphere

5.1: 1-dodecylthiol / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

5.2: 12 h / 20 °C / Inert atmosphere

With pyridine; bis-triphenylphosphine-palladium(II) chloride; tetrakis(acetonitrile)palladium(II) bis(tetrafluoroborate); copper(l) iodide; Wilkinson's catalyst; 1-fluoro-2,4,6-trimethylpyridinium hexafluorophosphate; water; hydrogen; silver fluoride; (S)-2-amino-1-(4,4-dimethylpiperidin-1-yl)-3,3-dimethylbutan-1-one; triethylamine; 1-dodecylthiol; In dichloromethane; N,N-dimethyl-formamide; m-xylene; acetonitrile;

DOI:10.1021/jacs.1c03178

upstream raw materials:

2-iodobenzaldehyde