Z-Gly-Val-Val-NH₂

Base Information

• Chemical Name: Z-Gly-Val-Val-NH₂
• CAS No.: 147424-37-1
• Molecular Formula: C₂₀H₃₀N₄O₅
• Molecular Weight: 406.482
• Mol file: 147424-37-1.mol

Synonyms:Z-Gly-Val-Val-NH₂

Chemical Property of Z-Gly-Val-Val-NH₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Z-Gly-Val-Val-NH₂

There total 4 articles about Z-Gly-Val-Val-NH₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

Cbz-Gly-ONSuc (2899-60-7) + H-Val-Val-NH2 (128211-98-3) → Z-Gly-Val-Val-NH2 (147424-37-1)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

DOI:10.1016/0223-5234(92)90113-F

Reference yield:

L-valinamide (4540-60-7,20108-78-5) → Z-Gly-Val-Val-NH2 (147424-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

2: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

3: 80 percent / N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

Reference yield:

2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate (3496-11-5) → Z-Gly-Val-Val-NH2 (147424-37-1)

Guidance literature:

Multi-step reaction with 3 steps

1: N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

2: H₂ / 5percent Pd/C / acetic acid; propan-2-ol / 760 Torr / Ambient temperature

3: 80 percent / N,N'-diisopropylethylamine DIEA, HOBt / dimethylformamide / 0 - 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In acetic acid; N,N-dimethyl-formamide; isopropyl alcohol;

DOI:10.1016/0223-5234(92)90113-F

upstream raw materials:

Cbz-Gly-ONSuc

H-Val-Val-NH₂

2,5-dioxopyrrolidin-1-yl (2S)-2-(((benzyloxy)carbonyl)amino)-3-methylbutanoate

L-valinamide

Downstream raw materials:

(S)-3-((S)-2-{(R)-2-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionylamino]-propionylamino}-3-phenyl-propionylamino)-N-{[(S)-1-((S)-1-carbamoyl-2-methyl-propylcarbamoyl)-2-methyl-propylcarbamoyl]-methyl}-succinamic acid tert-butyl ester

Z-Asp(OtBu)-Gly-Val-Val-NH₂