1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

Base Information

Chemical Name:1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea
CAS No.:1616235-12-1
Molecular Formula:C₂₃H₁₈FN₇O
Molecular Weight:427.441
Hs Code.:

Synonyms:1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

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Chemical Property of 1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

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Technology Process of 1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

There total 8 articles about 1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 1616235-42-7
6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-amine

: 103-71-9
phenyl isocyanate

: 1616235-12-1
1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

Guidance literature:: In dichloromethane; at 20 - 40 ℃; for 1.5h;

Reference yield:

: 863605-34-9
4-bromo-3-(4-fluorophenyl)-1-methyl-1H-pyrazole

: 1616235-12-1
1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

2: hydrogenchloride; methanol / 1,4-dioxane / 20 °C

3: dichloromethane / 1.5 h / 20 - 40 °C

With hydrogenchloride; methanol; potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; dichloromethane; water;

Reference yield:

: 154258-82-9
3-(4-fluorophenyl)-1H-pyrazole

: 1616235-12-1
1-(6-(3-(4-fluorophenyl)-1-methyl-1H-pyrazol-4-yl)imidazo[1,2-b]pyridazin-2-yl)-3-phenylurea

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0 - 20 °C / Inert atmosphere

2.2: 0 - 20 °C

3.1: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 100 °C / Inert atmosphere

4.1: hydrogenchloride; methanol / 1,4-dioxane / 20 °C

5.1: dichloromethane / 1.5 h / 20 - 40 °C

With hydrogenchloride; methanol; potassium phosphate; N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydride; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;