(4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

Base Information

Chemical Name:(4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester
CAS No.:130206-39-2
Molecular Formula:C₁₃H₁₃F₃N₂O₄S
Molecular Weight:350.318
Hs Code.:

Synonyms:(4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

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Chemical Property of (4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

Chemical Property:

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Technology Process of (4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

There total 4 articles about (4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 121-01-7
4-nitro-2-trifluoromethyl-aniline

: 130206-39-2
(4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) aq. HCl, aq. NaNO₂, 2.) CuCl, SO₂ (gas) / 1.) glacial AcOH, from -10 deg C to -5 deg C, 15 min, 2.) glacial AcOH, from 5 deg C to RT, 1.5 h

2: 60 percent / Et₃N / ethanol / 0.83 h / 20 °C

3: 48 percent / SnCl₂*2H₂O / methanol / 0.17 h / 55 °C

4: K₂CO₃

With hydrogenchloride; sulfur dioxide; potassium carbonate; triethylamine; copper(l) chloride; tin(ll) chloride; sodium nitrite; In methanol; ethanol;
DOI:10.1021/jm9502652

Reference yield:

: 444-46-2
4-nitro-2-(trifluoromethyl)benzenesulfonyl chloride

: 130206-39-2
(4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / Et₃N / ethanol / 0.83 h / 20 °C

2: 48 percent / SnCl₂*2H₂O / methanol / 0.17 h / 55 °C

3: K₂CO₃

With potassium carbonate; triethylamine; tin(ll) chloride; In methanol; ethanol;
DOI:10.1021/jm9502652

Reference yield:

: 130206-17-6
methyl N-((4-nitro-2-(trifluoromethyl)phenyl)sulfonyl)glycinate

: 130206-39-2
(4-Prop-2-ynylamino-2-trifluoromethyl-benzenesulfonylamino)-acetic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 48 percent / SnCl₂*2H₂O / methanol / 0.17 h / 55 °C

2: K₂CO₃

With potassium carbonate; tin(ll) chloride; In methanol;
DOI:10.1021/jm9502652