1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

Base Information

Chemical Name:1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol
CAS No.:131771-51-2
Molecular Formula:C₅₆H₈₀O₁₂Si₂
Molecular Weight:1001.41
Hs Code.:

Synonyms:1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

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Chemical Property of 1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

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Technology Process of 1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

There total 10 articles about 1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 3587-60-8
Benzyloxymethyl chloride

: 131771-50-1
1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

: 131771-51-2
1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 50 ℃;

Reference yield:

: 6974-32-9
1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose

: 131771-51-2
1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / trimethylsilyl trifluoromethylmethanesulfonate / 1,2-dichloro-ethane / Ambient temperature; a) molecular sieves 4 Angstroem, 1 h, b) 1 h

2: 85 percent / sodium methoxide / dioxane; methanol / 2 h / 20 °C

3: 82 percent / pyridine / 1 h / 20 °C

4: 87 percent / diisopropylethylamine / acetonitrile / 50 °C

With pyridine; trimethylsilyl trifluoromethylmethanesulfonate; sodium methylate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; 1,2-dichloro-ethane; acetonitrile;

Reference yield:

: 52689-55-1
methyl α-L-ribofuranoside

: 131771-51-2
1,3,4-tri-O-benzyl-5-O-pivaloyl-2-O-<2-O-(benzyloxymethyl)-3,5-O-(tetraisopropyldisiloxane-1,3-diyl)-β-D-ribofuranosyl>-D-ribitol

Guidance literature:: Multi-step reaction with 8 steps

1: 85 percent / sodium hydride / dimethylformamide / 12 h / 20 °C

2: 1M hydrogen chloride / acetic acid; H₂O / 2 h / 100 °C

3: 87 percent / sodium borohydride / ethanol / 1 h / 50 °C

4: 95 percent / pyridine / CH₂Cl₂ / Ambient temperature

5: 85 percent / trimethylsilyl trifluoromethylmethanesulfonate / 1,2-dichloro-ethane / Ambient temperature; a) molecular sieves 4 Angstroem, 1 h, b) 1 h

6: 85 percent / sodium methoxide / dioxane; methanol / 2 h / 20 °C

7: 82 percent / pyridine / 1 h / 20 °C

8: 87 percent / diisopropylethylamine / acetonitrile / 50 °C

With pyridine; hydrogenchloride; sodium tetrahydroborate; trimethylsilyl trifluoromethylmethanesulfonate; sodium methylate; sodium hydride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; ethanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;