Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

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Chemical Name:Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate
CAS No.:1415306-80-7
Molecular Formula:C₄₃H₄₅N₅O₂
Molecular Weight:663.863
Hs Code.:

Synonyms:Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

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Chemical Property of Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

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Technology Process of Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

There total 9 articles about Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415306-73-8
Ethyl 3-(5-bromo-2’-cyano-3,4-dimethyl-2,3’-bipyridine-5’-yl)-propanoate

: 1415306-71-6
N,N-dibenzyl-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)-propan-1-amine

: 1415306-80-7
Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

Guidance literature:: Ethyl 3-(5-bromo-2’-cyano-3,4-dimethyl-2,3’-bipyridine-5’-yl)-propanoate; With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; bis(pinacol)diborane; XPhos; In 1,4-dioxane; at 130 ℃; for 0.533333h; Inert atmosphere; Microwave irradiation;

N,N-dibenzyl-3-(1-chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-3-yl)-propan-1-amine; With potassium phosphate; In 1,4-dioxane; water; at 130 ℃; for 0.5h; Inert atmosphere; Microwave irradiation;
DOI:10.1002/anie.201304686

Reference yield:

: 2396-63-6
hepta-1,6-diyne

: 1415306-80-7
Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,2-dichloro-ethane / 20.5 h / 0 - 20 °C / Inert atmosphere

2.1: borane-dimethyl sulfide complex / tetrahydrofuran / 24 h / 60 °C / Inert atmosphere

2.2: 3 h / 70 °C / Inert atmosphere

3.1: triethylamine / acetonitrile / 3 h / 60 °C

4.1: n-butyllithium; 2-(N,N-dimethylamino)ethanol / hexane; diethyl ether / 0.5 h / -65 °C / Inert atmosphere

4.2: 0.5 h / -75 °C / Inert atmosphere

5.1: potassium acetate; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 0.53 h / 130 °C / Inert atmosphere; Microwave irradiation

5.2: 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; n-butyllithium; 2-(N,N-dimethylamino)ethanol; borane-dimethyl sulfide complex; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); potassium acetate; triethylamine; bis(pinacol)diborane; XPhos; In tetrahydrofuran; 1,4-dioxane; diethyl ether; hexane; 1,2-dichloro-ethane; acetonitrile; 5.1: |Suzuki-Miyaura Coupling / 5.2: |Suzuki-Miyaura Coupling;
DOI:10.1002/anie.201304686

Reference yield:

: 1415306-66-9
ethyl 3-[6-cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-yl]-propanoate

: 1415306-80-7
Ethyl 3-(6-cyano-5-(5-(3-(3-(dibenzylamino)propyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-1-yl)-3,4-dimethylpyridin-2-yl)pyridine-3-yl)propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: palladium diacetate; potassium phosphate; triphenylphosphine / 1,4-dioxane; water / 0.17 h / 20 °C / Inert atmosphere

1.2: 2.5 h / 80 °C / Inert atmosphere

2.1: potassium acetate; bis(pinacol)diborane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 1,4-dioxane / 0.53 h / 130 °C / Inert atmosphere; Microwave irradiation

2.2: 0.5 h / 130 °C / Inert atmosphere; Microwave irradiation

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; potassium acetate; palladium diacetate; triphenylphosphine; bis(pinacol)diborane; XPhos; In 1,4-dioxane; water; 1.1: |Suzuki Coupling / 1.2: |Suzuki Coupling / 2.1: |Suzuki-Miyaura Coupling / 2.2: |Suzuki-Miyaura Coupling;
DOI:10.1002/anie.201304686