methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

Base Information

Chemical Name:methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate
CAS No.:1252657-63-8
Molecular Formula:C₂₂H₃₀N₄O₃
Molecular Weight:398.505
Hs Code.:

Synonyms:methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

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Chemical Property of methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

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Technology Process of methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

There total 2 articles about methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1252658-16-4
1-(2-tert-butylphenyl)-4-[(2-methyl-1H-imidazol-4-yl)carbonyl]piperazine

: 96-32-2
bromoacetic acid methyl ester

: 1252657-63-8
methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

Reference yield:

: 1457-58-5
2-methyl-1H-imidazole-4-carboxylic acid

: 1252657-63-8
methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 16 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 50 °C

With potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 1252657-63-8
methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate

: 1252657-64-9
(4-{[4-(2-tert-Butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetic acid

Guidance literature:: methyl (4-{[4-(2-tert-butylphenyl)piperazin-1-yl]carbonyl}-2-methyl-1H-imidazol-1-yl)acetate; With lithium hydroxide; In tetrahydrofuran; at 0 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; water;