(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

Base Information

Chemical Name:(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester
CAS No.:1400705-98-7
Molecular Formula:C₂₆H₃₇N₅O₆
Molecular Weight:515.61
Hs Code.:

(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

Synonyms:(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

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Chemical Property of (S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

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Technology Process of (S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

There total 8 articles about (S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1400705-72-7
2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carboxylic acid

: methyl (S)-2-amino-3-tert-butoxycarbonylaminopropanoate hydrochloride

: 1400705-98-7
(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

Guidance literature:: With benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 168130-75-4
4,6-dimethyl-2-hydroxypyrimidine-5-carboxylic acid ethyl ester

: 1400705-98-7
(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine; trichlorophosphate / 2 h / 110 °C

2.1: ethanol / 1 h / 160 °C / microwave irradiation

2.2: 20 °C

3.1: triethylamine / Schwartz's reagent / tetrahydrofuran / 20.3 h / 150 °C / microwave irradiation

4.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 0.25 h / 135 °C / Inert atmosphere; microwave irradiation

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 7500.75 Torr / H-Cube

6.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4 h / 95 °C

6.2: 20 °C / pH 2 - 4

7.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate; Schwartz's reagent; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 108381-23-3
2-chloro-4,6-dimethylpyrimidine-5-carboxylic acid ethyl ester

: 1400705-98-7
(S)-3-tert-butoxycarbonylamino-2-({2-[3-(3-hydroxy-4-methyl-phenyl)propylamino]-4,6-dimethyl-pyrimidine-5-carbonyl}amino)propionic acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol / 1 h / 160 °C / microwave irradiation

1.2: 20 °C

2.1: triethylamine / Schwartz's reagent / tetrahydrofuran / 20.3 h / 150 °C / microwave irradiation

3.1: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / N,N-dimethyl-formamide; water / 0.25 h / 135 °C / Inert atmosphere; microwave irradiation

4.1: hydrogen / palladium 10% on activated carbon / ethanol / 20 °C / 7500.75 Torr / H-Cube

5.1: water; lithium hydroxide monohydrate / 1,4-dioxane / 4 h / 95 °C

5.2: 20 °C / pH 2 - 4

6.1: triethylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 2 h / 20 °C

With lithium hydroxide monohydrate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; Schwartz's reagent; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;