2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

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Chemical Name:2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione
CAS No.:1402001-57-3
Molecular Formula:C₂₁H₁₈F₄N₄O₃
Molecular Weight:450.393
Hs Code.:

Synonyms:2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

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Chemical Property of 2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

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Technology Process of 2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

There total 4 articles about 2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1402004-17-4
2-({2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}amino)ethanol

: 5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid, hydrobromide salt

: 1402001-57-3
2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

Guidance literature:: 2-({2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}amino)ethanol; 5-(4-methyl-1H-imidazol-1-yl)-6-oxo-1,6-dihydropyridine-2-carboxylic acid, hydrobromide salt; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

With HATU; In dichloromethane; for 16h; Inert atmosphere;
DOI:10.1021/jm401782h

Reference yield:

: 130047-19-7
4-fluoro-2-(trifluoromethyl)phenol

: 1402001-57-3
2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine / tetrahydrofuran / 0.08 h

1.2: 16.33 h / 20 °C

2.1: 1.5 h / 80 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C

3.2: 16 h / 20 °C

With N-ethyl-N,N-diisopropylamine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1262197-81-8
methyl 6-methoxy-5-(4-methyl-1H-imidazol-1-yl)pyridine-2-carboxylate

: 1402001-57-3
2-{2-[4-fluoro-2-(trifluoromethyl)phenoxy]ethyl}-7-(4-methyl-1H-imidazol-1-yl)-3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-dione

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogen bromide; acetic acid / water / 4 h / Reflux

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.08 h / 20 °C

2.2: 16 h / 20 °C

With hydrogen bromide; acetic acid; N-ethyl-N,N-diisopropylamine; In dichloromethane; water;