Sultiame

Base Information

Chemical Name:Sultiame
CAS No.:61-56-3
Molecular Formula:C10H14N2O4S2
Molecular Weight:290.364
Hs Code.:2935009090
European Community (EC) Number:200-511-0
UNII:I00Q766CZ2
DSSTox Substance ID:DTXSID4023626
Nikkaji Number:J4.400H
Wikipedia:Sultiame
Wikidata:Q2364943
NCI Thesaurus Code:C152469
Pharos Ligand ID:KQY8Q9QRB3M1
Metabolomics Workbench ID:151469
ChEMBL ID:CHEMBL328560
Mol file:61-56-3.mol

Synonyms:Ospolot;p-(tetrahydro-2H-1,2-thiazin-2-yl)benzenesulfonamide, S,S-dioxide;sulthiame;sultiam;sultiame

Suppliers and Price of Sultiame

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Sulthiame
250mg
$ 1455.00

Medical Isotopes, Inc.
Sulthiame
25 mg
$ 390.00

ChemScene
Sultiame 99.11%
5mg
$ 168.00

American Custom Chemicals Corporation
SULTIAME 95.00%
250MG
$ 1963.50

American Custom Chemicals Corporation
SULTIAME 95.00%
25MG
$ 329.70

Total 21 raw suppliers

Chemical Property of Sultiame

Chemical Property:

Vapor Pressure:6.39E-11mmHg at 25°C
Melting Point:180-182°
Refractive Index:1.609
Boiling Point:520.162 °C at 760 mmHg
PKA:9.90±0.10(Predicted)
Flash Point:268.384 °C
PSA：114.30000
Density:1.472 g/cm³
LogP:3.19090
Storage Temp.:2-8°C
XLogP3:0.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:290.03949928
Heavy Atom Count:18
Complexity:481

Purity/Quality:

97% ^*data from raw suppliers

Sulthiame ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CCS(=O)(=O)N(C1)C2=CC=C(C=C2)S(=O)(=O)N
Recent ClinicalTrials:Efficacy, Safety and Tolerability of Sulthiame in Patients With Obstructive Sleep Apnea (OSA)
Recent EU Clinical Trials:Efficacy, Safety and Tolerability of 3 doses of Sulthiame in Patients with Obstructive Sleep Apnea. A Randomized, Double-Blind, Placebo Controlled, Dose-Ranging Study
Uses Sultiame is a benzenesulfonamide derivative. Sultiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy. Sulthiame is a benzenesulfonamide derivative. Sulthiame acts as an inhibitor of the enzyme carbonic anhydrase. Sulthiame is used as an anticonvulsant in the treatment of benign and symptomatic focal epilepsy.

Technology Process of Sultiame

There total 2 articles about Sultiame which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1633-84-7
4-chloro-1-butanesulfonyl chloride

: 63-74-1
sulfanilamide

: 61-56-3
sulthiame

Guidance literature:: With pyridine; at 40 ℃; for 29h;
DOI:10.1021/jacs.0c01332

Reference yield:

: 61-56-3
sulthiame

Guidance literature:: 4-Sulfamidoanilin,Cl-4-SO2Cl;

Reference yield: 40.0%

: 61-56-3
sulthiame

: 61755-53-1
5-methylhex-4-en-1-yl 4-methylbenzenesulfonate

: 4-(1,1-dioxido-1,2-thiazinan-2-yl)-N-(5-methylhex-4-en-1-yl)benzenesulfonamide

Guidance literature:: sulthiame; With potassium hydroxide; In N,N-dimethyl-formamide; at 120 ℃; for 0.5h;

5-methylhex-4-en-1-yl 4-methylbenzenesulfonate; In N,N-dimethyl-formamide; for 1h;
DOI:10.1021/jacs.0c01332