(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

Base Information

Chemical Name:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one
CAS No.:943917-45-1
Molecular Formula:C₂₆H₁₆ClF₉INO₂
Molecular Weight:707.762
Hs Code.:

Synonyms:(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

There total 2 articles about (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5-nitro-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

: 943917-45-1
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: (4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5-nitro-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one; With tin(II) chloride dihdyrate; In ethanol; at 20 ℃; for 4h; Inert atmosphere;

With n-Amyl nitrite; iodine; In chloroform; for 1h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.1c00959

Reference yield:

: 875446-35-8
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-[2-iodo-5-(trifluoromethyl)benzyl]-4-methyl-1,3-oxazolidin-2-one

: 943917-45-1
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; ethanol; toluene / 4 h / Inert atmosphere; Reflux

2.1: tin(II) chloride dihdyrate / ethanol / 4 h / 20 °C / Inert atmosphere

2.2: 1 h / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; sodium carbonate; In ethanol; water; toluene;
DOI:10.1021/acs.jmedchem.1c00959

Reference yield: 76.0%

: 943917-45-1
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[2'-chloro-5'-iodo-4-(trifluoromethyl)biphenyl-2-yl] methyl}-4-methyl-1,3-oxazolidin-2-one

: 473596-87-1
4-methoxycarbonyl-2-methylbenzeneboronic acid pinacol ester

: 943915-95-5
methyl 2''-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-4'-chloro-2-methyl-4''-(trifluoromethyl)-1,1':3',1''-terphenyl-4-carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 2h; Inert atmosphere; Reflux;
DOI:10.1021/acs.jmedchem.1c00959