(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Base Information

Chemical Name:(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde
CAS No.:866021-61-6
Molecular Formula:C₂₈H₄₈O₇Si
Molecular Weight:524.77
Hs Code.:

(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Synonyms:(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Suppliers and Price of (S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

There total 14 articles about (S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 866022-13-1
(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutan-1-ol

: 866021-61-6
(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Guidance literature:: With sodium hydrogencarbonate; Dess-Martin periodane; In dichloromethane;
DOI:10.1021/ol051405x

Reference yield:

: 866021-71-8
(4S,5S)-5-((S)-1-methoxybut-3-enyl)-2,2-dimethyl-1,3-dioxolane-4-carbaldehyde

: 866021-61-6
(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Guidance literature:: Multi-step reaction with 10 steps

1.1: c-Hex₂BCl; Et₃N / diethyl ether / 0 °C

1.2: -78 °C

1.3: 79 percent / aq. H₂O₂

2.1: 2,6-lutidine / CH₂Cl₂

3.1: K₂CO₃ / methanol

4.1: NaBH₄

5.1: NaIO₄

6.1: NaBH₄

7.1: PPTS / CH₂Cl₂

8.1: tetrahydrofuran

9.1: aq. H₂O₂; NaOH

10.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

With 2,6-dimethylpyridine; sodium hydroxide; sodium tetrahydroborate; sodium periodate; dicyclohexylboron chloride; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 10.1: Dess-Martin oxidation;
DOI:10.1021/ol051405x

Reference yield:

: 866022-02-8
(S)-1-((4S,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)but-3-en-1-ol

: 866021-61-6
(S)-4-{(4S,5R)-5-[(1S,2S)-3-(4-methoxybenzyloxy)-1-(tert-butyldimethylsilanyloxy)-2-methylpropyl]-2,2-dimethyl-1,3-dioxolan-4-yl}-4-methoxybutyraldehyde

Guidance literature:: Multi-step reaction with 13 steps

1.1: NaH / tetrahydrofuran

2.1: TBAF / tetrahydrofuran / 0 °C

3.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

4.1: c-Hex₂BCl; Et₃N / diethyl ether / 0 °C

4.2: -78 °C

4.3: 79 percent / aq. H₂O₂

5.1: 2,6-lutidine / CH₂Cl₂

6.1: K₂CO₃ / methanol

7.1: NaBH₄

8.1: NaIO₄

9.1: NaBH₄

10.1: PPTS / CH₂Cl₂

11.1: tetrahydrofuran

12.1: aq. H₂O₂; NaOH

13.1: Dess-Martin periodinane; NaHCO₃ / CH₂Cl₂

With 2,6-dimethylpyridine; sodium hydroxide; sodium tetrahydroborate; sodium periodate; dicyclohexylboron chloride; tetrabutyl ammonium fluoride; dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; sodium hydrogencarbonate; potassium carbonate; Dess-Martin periodane; triethylamine; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; 3.1: Dess-Martin oxidation / 13.1: Dess-Martin oxidation;
DOI:10.1021/ol051405x