dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine

Base Information

• Chemical Name: dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine
• CAS No.: 1217887-08-5
• Molecular Formula: C₂₁H₃₃O₃P
• Molecular Weight: 364.465
• Mol file: 1217887-08-5.mol

Synonyms:dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine

Chemical Property of dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine

There total 5 articles about dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) + chlorodicyclohexylphosphane (16523-54-9) → dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine (1217887-08-5)

Guidance literature:

1,2,3-trimethoxybenzene; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 11.5833h; Inert atmosphere;

chlorodicyclohexylphosphane; In tetrahydrofuran; diethyl ether; hexane; at 30 ℃; for 11.5h;

DOI:10.1016/j.tetlet.2009.12.143

Reference yield:

1-lithium-2,4,6-trimethoxybenzene (34425-71-3) + chlorodicyclohexylphosphane (16523-54-9) → dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine (1217887-08-5)

Guidance literature:

In tetrahydrofuran; hexane; at -78 - 20 ℃; for 18.5h; Product distribution / selectivity;

Reference yield:

1,2,3-trimethoxybenzene (621-23-8) → dicyclohexyl(2,4,6-trimethoxyphenyl)phosphine (1217887-08-5)

Guidance literature:

Multi-step reaction with 2 steps

1: n-butyllithium / hexane; tetrahydrofuran / 4.5 h / -78 - 20 °C / Inert atmosphere

2: hexane; tetrahydrofuran / 18.5 h / -78 - 20 °C

With n-butyllithium; In tetrahydrofuran; hexane;

upstream raw materials:

1,2,3-trimethoxybenzene

chlorodicyclohexylphosphane

cyclohexylmagnesiumchloride

1-lithium-2,4,6-trimethoxybenzene

Downstream raw materials:

dicyclohexyl(2,4,6-trimethoxyphenyl)phosphonium tetrafluoroborate

PdCl₂(LB-PHOS)2