2-(2-amino-3-chlorobenzoyl)benzoic acid

Base Information

• Chemical Name: 2-(2-amino-3-chlorobenzoyl)benzoic acid
• CAS No.: 85-51-8
• Molecular Formula: C28H24O2
• Molecular Weight: 275.691
• Mol file: 85-51-8.mol

Synonyms:

Chemical Property of 2-(2-amino-3-chlorobenzoyl)benzoic acid

Chemical Property:

• Vapor Pressure: 8.28E-13mmHg at 25°C
• Boiling Point: 547.2°C at 760 mmHg
• Flash Point: 284.7°C
• Density: 1.418g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-amino-3-chlorobenzoyl)benzoic acid

There total 3 articles about 2-(2-amino-3-chlorobenzoyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(o-chlorophenyl)-phthalimide (22698-95-9) → 2-amino-3-chlorobenzophenone-2'-carboxylic acid (85-51-8)

Guidance literature:

With aluminium trichloride; sodium chloride; at 310 ℃; Erhitzen des nach dem Behandeln mit Eis erhaltenen Reaktionsprodukts mit wss. Natronlauge;

Reference yield:

4-chloro-5H-dibenzo[b,e]azepine-6,11-dione (77043-26-6) → 2-amino-3-chlorobenzophenone-2'-carboxylic acid (85-51-8)

Guidance literature:

With sodium hydroxide;

Reference yield:

1-chloroanthracene-9,10-dione (82-44-0) → 2-amino-3-chlorobenzophenone-2'-carboxylic acid (85-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: concentrated sulfuric acid; sodium azide

2: aqueous NaOH

With sodium hydroxide; sodium azide; sulfuric acid;

upstream raw materials:

N-(o-chlorophenyl)-phthalimide

4-chloro-5H-dibenzo[b,e]azepine-6,11-dione

1-chloroanthracene-9,10-dione

Downstream raw materials:

1-amino-2-chloro-9,10-anthraquinone

Refernces

THE BIOSYNTHESIS OF THE ALKALOIDS OF CORYDALIS MEIFOLIA WALL.

10.1016/S0040-4020(01)87469-X

The study investigates the biosynthesis of alkaloids in Corydalis meifolia Wall., a plant used in traditional medicine. The researchers used tracer experiments to demonstrate that the alkaloids corlumine, cavidine, and yenshusomine are stereospecifically biosynthesized from (R)-(?)-reticuline. They fed various labeled precursors, including tyrosine, norreticuline, and reticuline, to young branches of the plant and observed the incorporation of these precursors into the target alkaloids. The results showed that certain precursors, like norreticuline and reticuline, were efficiently metabolized into the alkaloids, while others were not. The study also established the regiospecificity of the biosynthetic pathway by tracking the labeled atoms through various chemical transformations, confirming that reticuline is a true precursor of these alkaloids. The findings provide valuable insights into the biogenetic pathway of these medically relevant compounds.