tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

Base Information

Chemical Name:tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane
CAS No.:934631-70-6
Molecular Formula:C₂₈H₃₈O₄Si
Molecular Weight:466.693
Hs Code.:

<i>tert</i>-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

Synonyms:tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

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Technology Process of tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

There total 3 articles about tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 934631-69-3
6-(tert-butyl-diphenyl-silanyloxymethyl)-2-ethynyl-3,3-dimethyl-tetrahydro-pyran-4-ol

: 107-30-2
chloromethyl methyl ether

: 934631-70-6
tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;
DOI:10.1021/ol063143k

Reference yield:

: 934631-68-2
tert-butyl-(4-ethynyl-5,5-dimethyl-3,7-dioxa-bicyclo[4.1.0]hept-2-ylmethoxy)-diphenyl-silane

: 934631-70-6
tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / DIBAL-H / diethyl ether; hexane / 0 °C

2: 97 percent / DIEA / dimethylformamide / 0 - 20 °C

With diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ol063143k

Reference yield:

: 2-(tert-butyl-diphenyl-silanyloxymethyl)-6-ethynyl-5,5-dimethyl-tetrahydro-pyran-3,4-diol

: 934631-70-6
tert-butyl-(6-ethynyl-4-methoxymethoxy-5,5-dimethyl-tetrahydro-pyran-2-ylmethoxy)-diphenyl-silane

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; H₂O; various solvent(s) / 0 °C

1.2: 70 percent / toluenesulfonyl chloride / tetrahydrofuran; H₂O; various solvent(s) / 0.5 h

2.1: 80 percent / DIBAL-H / diethyl ether; hexane / 0 °C

3.1: 97 percent / DIEA / dimethylformamide / 0 - 20 °C

With sodium hydride; diisobutylaluminium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol063143k