(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Base Information

Chemical Name:(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid
CAS No.:1412974-65-2
Molecular Formula:C₂₅H₂₈FN₃O₆S
Molecular Weight:517.578
Hs Code.:

(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Synonyms:(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Chemical Property of (1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

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Technology Process of (1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

There total 25 articles about (1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1412976-93-2
methyl (1aRS,7bSR)-5-{2-[((S)-1-ethylpyrrolidin-3-ylcarbamoyl)methyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate

: 1412974-65-2
(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: methyl (1aRS,7bSR)-5-{2-[((S)-1-ethylpyrrolidin-3-ylcarbamoyl)methyl]-4-fluorobenzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylate; With lithium hydroxide monohydrate; water; In 1,4-dioxane; at 130 ℃; for 0.666667h; Microwave irradiation;

With formic acid; In methanol;

Reference yield:

: 64241-01-6
methyl 2-amino-6-hydroxybenzoate

: 1412974-65-2
(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1: sodium hydrogencarbonate / ethyl acetate; water / 2.5 h / 20 °C

2: potassium carbonate / toluene; acetone / 8 h / Reflux

3: toluene / 3 h / 85 °C / Inert atmosphere

4: sodium hydroxide; water; N-benzyl-N,N,N-triethylammonium chloride; Bromoform / 2 h / 60 °C

5: zinc; ammonium chloride / ethanol / 6 h / Reflux; Inert atmosphere

6: sulfuric acid / methanol / 60 h / Reflux; Inert atmosphere

7: dichloromethane; pyridine / 96 h / 20 °C

8: sodium hydroxide; methanol / 2 h / 50 °C

9: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h / 20 °C

10: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.67 h / 130 °C / Microwave irradiation

With methanol; lithium hydroxide monohydrate; Bromoform; sulfuric acid; N-benzyl-N,N,N-triethylammonium chloride; water; sodium hydrogencarbonate; potassium carbonate; ammonium chloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; sodium hydroxide; zinc; In 1,4-dioxane; pyridine; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; toluene;

Reference yield:

: 1336912-68-5
tert-butyl ((S)-1-ethylpyrrolidin-3-yl)carbamate

: 1412974-65-2
(1aRS,7bSR)-5-{2-[((S)-1-ethylpyrmlidin-3-ylcarbamoyl)methyl]-4-fluoro-benzenesulfonylamino}-1,1a,2,7b-tetrahydrocyclopropa[c]chromene-4-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 0.5 h / 20 °C

2: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 144 h / 20 °C

3: water; lithium hydroxide monohydrate / 1,4-dioxane / 0.67 h / 130 °C / Microwave irradiation

With lithium hydroxide monohydrate; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In 1,4-dioxane; dichloromethane;