(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

Base Information

Chemical Name:(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate
CAS No.:171827-01-3
Molecular Formula:C₂₈H₃₆O₁₀S
Molecular Weight:564.654
Hs Code.:

Synonyms:(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

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Chemical Property of (E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

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Technology Process of (E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

There total 10 articles about (E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 34097-60-4
methyl benzenesulfonylacetate

: 171826-98-5
(E)-methyl 3-(4-bromo-3-methyl-2-butenyl)-4-methoxy-2-((2-methoxyethoxy)methoxy)-5-methylbenzoate

: 171827-01-3
(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

Guidance literature:: With sodium hydride; Yield given. Multistep reaction; 1.) DMF 2.) DMF, RT, 12 h;
DOI:10.1021/jm9501339

Reference yield:

: 39503-63-4
methyl 5-formyl-2,4-dimethoxybenzoate

: 171827-01-3
(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

Guidance literature:: Multi-step reaction with 10 steps

1: 94 percent / H₂, AcOH / 10percent Pd/C / ethyl acetate / 48 h

2: 86 percent / BF₃ / CH₂Cl₂ / 2 h / Ambient temperature

3: K₂CO₃ / acetone / 84 h / Heating

4: 30.47 g / 4 h / 210 °C

5: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 5 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 15 min

6: 90 percent / benzene / 28 h / Heating

7: 1.) NaH / 1.) THF, 0 deg C, 20 min, 2.) THF, from 0 deg C to RT, 1 h

8: 85 percent / NaBH₄ / methanol / 1 h / 0 - 20 °C

9: 79 percent / N,N-diisopropylethylamine, CBr₄, Ph₃P / CH₂Cl₂ / 10.75 h / -76 - 20 °C

10: 1.) NaH / 1.) DMF 2.) DMF, RT, 12 h

With methanol; sodium tetrahydroborate; carbon tetrabromide; boron trifluoride; hydrogen; sodium hydride; potassium carbonate; ozone; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In methanol; dichloromethane; ethyl acetate; acetone; benzene;
DOI:10.1021/jm9501339

Reference yield:

: 39503-29-2
methyl 2-hydroxy-4-methoxy-5-methylbenzoate

: 171827-01-3
(E)-methyl 2-(phenylsulfonyl)-4-methyl-6-<3-<1-(methoxycarbonyl)-2-(2-methoxyethoxymethoxy)-4-methoxy-5-methylphenyl>>-4-hexenoate

Guidance literature:: Multi-step reaction with 8 steps

1: K₂CO₃ / acetone / 84 h / Heating

2: 30.47 g / 4 h / 210 °C

3: 1.) O₃, MeOH, 2,) PPh₃ / 1.) CH₂Cl₂, -76 deg C, 5 min, 2.) CH₂Cl₂, MeOH, -76 deg C, 15 min

4: 90 percent / benzene / 28 h / Heating

5: 1.) NaH / 1.) THF, 0 deg C, 20 min, 2.) THF, from 0 deg C to RT, 1 h

6: 85 percent / NaBH₄ / methanol / 1 h / 0 - 20 °C

7: 79 percent / N,N-diisopropylethylamine, CBr₄, Ph₃P / CH₂Cl₂ / 10.75 h / -76 - 20 °C

8: 1.) NaH / 1.) DMF 2.) DMF, RT, 12 h

With methanol; sodium tetrahydroborate; carbon tetrabromide; sodium hydride; potassium carbonate; ozone; N-ethyl-N,N-diisopropylamine; triphenylphosphine; In methanol; dichloromethane; acetone; benzene;
DOI:10.1021/jm9501339