2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

Base Information

Chemical Name:2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione
CAS No.:1432112-05-4
Molecular Formula:C₂₉H₂₂ClN₅O₃
Molecular Weight:523.978
Hs Code.:

Synonyms:2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

There total 6 articles about 2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

: 1218926-59-0
2-(4-amino-2-chlorophenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

: 1432111-98-2
3-bromo-1-(4-methoxybenzyl)-1H-pyrazolo[4,3-b]pyridine

: 1432112-05-4
2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 3h; Inert atmosphere; Reflux;

Reference yield:

: 272-52-6
1H-pyrazolo-[4,3-b]-pyridine

: 1432112-05-4
2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: bromine / methanol; water / 0.67 h / 0 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 100 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; bromine; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 121-87-9
2-Chloro-4-nitroaniline

: 1432112-05-4
2-(2-chloro-4-{[1-(4-methoxybenzyl)-1H-pyrazolo[4,3b]pyridin-3-yl]amino}phenyl)-4-methyl-1H-isoindole-1,3(2H)-dione

Guidance literature:: Multi-step reaction with 3 steps

1: acetic acid / 48 h / Reflux; Inert atmosphere

2: palladium on activated charcoal; hydrogen / ethyl acetate / 24 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 3 h / Reflux; Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium on activated charcoal; hydrogen; caesium carbonate; acetic acid; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethyl acetate;