1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine

Base Information

• Chemical Name: 1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine
• CAS No.: 84394-31-0
• Molecular Formula: C₃₀H₃₅NO₃
• Molecular Weight: 457.613

Synonyms:1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine

Chemical Property of 1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine

Chemical Property:

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Technology Process of 1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine

There total 2 articles about 1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(2-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenylchromene (84394-18-3) → 1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine (84394-31-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / H₂ / 10percent Pd/C / methanol / 8 h / 3102.9 Torr

2: K₂CO₃ / acetone / 14 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; acetone;

DOI:10.1021/jm00358a026

Reference yield:

1-(2-chloroethyl)pyrrolidine hydrochloride (7250-67-1) + 2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenol (84394-19-4) → 1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine (84394-31-0)

Guidance literature:

With potassium carbonate; In acetone; for 14h; Heating;

DOI:10.1021/jm00358a026

Reference yield: 90.0%

1-{2-[2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenoxy]-ethyl}-pyrrolidine (84394-31-0) → trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride (84394-11-6)

Guidance literature:

With n-butyllithium; In hexane; dimethyl sulfoxide; for 16h; Ambient temperature;

DOI:10.1021/jm00358a026

upstream raw materials:

1-(2-chloroethyl)pyrrolidine hydrochloride

2-((3S,4R)-7-Methoxy-2,2-dimethyl-3-phenyl-chroman-4-yl)-phenol

4-(2-hydroxyphenyl)-7-methoxy-2,2-dimethyl-3-phenylchromene

Downstream raw materials:

trans-2,2-dimethyl-3-phenyl-4--7-methoxychroman hydrochloride

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