[(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene

Base Information

• Chemical Name: [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene
• CAS No.: 174197-74-1
• Molecular Formula: C₁₈H₂₄O₃S
• Molecular Weight: 320.453
• Mol file: 174197-74-1.mol

Synonyms:[(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene

Chemical Property of [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene

There total 5 articles about [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

(E)-2,4-pentadienyltrimethylsilane (72952-73-9) + 2,2-bis[(E)-3-(phenylsulfonyl)-2-butenyloxy]propane (174197-86-5) → [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene (174197-74-1)

Guidance literature:

With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 ℃; for 2h;

DOI:10.1016/0040-4020(95)00920-5

Reference yield:

penta-1,3-diene (504-60-9,17410-45-6,25212-15-1,64940-84-7) → [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene (174197-74-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) K, Et₃N / 1.) THF, reflux, 5 h, 2.) THF, 0 deg C, 1 h

2: 78 percent / TMSOTf / CH₂Cl₂ / 2 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; triethylamine; In dichloromethane;

DOI:10.1016/0040-4020(95)00920-5

Reference yield:

ethyl phenyl sulfone (599-70-2) → [(E)-4-((E)-1,1-Dimethyl-hexa-3,5-dienyloxy)-but-2-ene-2-sulfonyl]-benzene (174197-74-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) LDA, 2.) diethyl chlorophosphate

2: Et₃N / CH₂Cl₂ / 1 h

3: 48 percent / TMSOTf / CH₂Cl₂ / 3 h / -78 °C

4: 78 percent / TMSOTf / CH₂Cl₂ / 2 h / -78 °C

With trimethylsilyl trifluoromethanesulfonate; diethyl chlorophosphate; triethylamine; lithium diisopropyl amide; In dichloromethane;

DOI:10.1016/0040-4020(95)00920-5

upstream raw materials:

(E)-2,4-pentadienyltrimethylsilane

2,2-bis[(E)-3-(phenylsulfonyl)-2-butenyloxy]propane

penta-1,3-diene

ethyl phenyl sulfone