(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1213254-43-3
Molecular Formula:C₂₄H₃₁N₅O₄
Molecular Weight:453.541
Hs Code.:

Synonyms:(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

There total 11 articles about (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1213255-73-2
1-(hex-5-ynyl)pyrimidine-2,4(1H,3H)-dione

: 1213256-24-6
(S)-1-azido-2-(3-(cyclopropylmethoxy)phenyl)butan-2-ol

: 1213254-43-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In 1,4-dioxane; at 80 ℃;
DOI:10.1021/jm3004174

Reference yield:

: C₁₅H₂₂O₅S

: 1213254-43-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dichloromethane; N,N-dimethyl-formamide / 12 h / 90 °C

2: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C

With sodium azide; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3004174

Reference yield:

: C₁₇H₁₆N₂O₃

: 1213254-43-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)-2-hydroxybutyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: methylamine / methanol / 1 h / 20 °C

2: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C

With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); methylamine; In 1,4-dioxane; methanol;
DOI:10.1021/jm3004174