6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

Base Information

Chemical Name:6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile
CAS No.:1392426-79-7
Molecular Formula:C₂₀H₂₁N₃O₂
Molecular Weight:335.406
Hs Code.:

Synonyms:6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

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Chemical Property of 6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

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Technology Process of 6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

There total 4 articles about 6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1392426-90-2
N-(1,3-benzodioxol-5-ylmethyl)-6-bromo-N-cyclohexyl-pyridin-2-amine

: 557-21-1
dicyanozinc

: 1392426-79-7
6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; zinc; In N,N-dimethyl acetamide; at 120 ℃; for 2.5h; Inert atmosphere;
DOI:10.1039/c2ob00034b

Reference yield:

: 2620-50-0
1,3-benzodioxol-5-ylmethyl amine

: 1392426-79-7
6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1.5 h / 25 °C / Molecular sieve; Inert atmosphere

1.2: 25 h / 17 °C / Molecular sieve; Inert atmosphere

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate / toluene / 22 h / 25 - 80 °C / Inert atmosphere

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; zinc / N,N-dimethyl acetamide / 2.5 h / 120 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate; zinc; In dichloromethane; N,N-dimethyl acetamide; toluene; 2.1: Buchwald-Hartwig reaction;
DOI:10.1039/c2ob00034b

Reference yield:

: 108-94-1,11119-77-0,9003-41-2,9075-99-4
cyclohexanone

: 1392426-79-7
6-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]pyridine-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1.5 h / 25 °C / Molecular sieve; Inert atmosphere

1.2: 25 h / 17 °C / Molecular sieve; Inert atmosphere

2.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate / toluene / 22 h / 25 - 80 °C / Inert atmosphere

3.1: 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; zinc / N,N-dimethyl acetamide / 2.5 h / 120 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; sodium t-butanolate; zinc; In dichloromethane; N,N-dimethyl acetamide; toluene; 2.1: Buchwald-Hartwig reaction;
DOI:10.1039/c2ob00034b