(2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

Base Information

Chemical Name:(2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol
CAS No.:155781-28-5
Molecular Formula:C₂₂H₃₉IO₄Si
Molecular Weight:522.539
Hs Code.:

Synonyms:(2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

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Chemical Property of (2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

Chemical Property:

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Technology Process of (2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

There total 3 articles about (2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 155781-16-1
Triisopropyl-[(S)-3-(4-methoxy-phenoxy)-2-((2R,3S)-3-methyl-oxiranyl)-propoxy]-silane

: 155781-28-5
(2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

Guidance literature:: With tri-n-butyl-tin hydride; magnesium iodide; In diethyl ether; toluene; at -78 ℃; for 0.666667h; Yield given;
DOI:10.1016/S0040-4020(01)85080-8

Reference yield:

: 150-76-5
4-methoxy-phenol

: 155781-28-5
(2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Ph₃P, DEAD / CH₂Cl₂ / 15 h / Ambient temperature

2: MgI₂, Bu₃SnH / diethyl ether; toluene / 0.67 h / -78 °C

With tri-n-butyl-tin hydride; triphenylphosphine; magnesium iodide; diethylazodicarboxylate; In diethyl ether; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)85080-8

Reference yield:

: 155125-17-0
(S)-2-((2R,3S)-3-Methyl-oxiranyl)-3-triisopropylsilanyloxy-propan-1-ol

: 155781-28-5
(2S,3R,4R)-4-Iodo-2-(4-methoxy-phenoxymethyl)-1-triisopropylsilanyloxy-pentan-3-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 87 percent / Ph₃P, DEAD / CH₂Cl₂ / 15 h / Ambient temperature

2: MgI₂, Bu₃SnH / diethyl ether; toluene / 0.67 h / -78 °C

With tri-n-butyl-tin hydride; triphenylphosphine; magnesium iodide; diethylazodicarboxylate; In diethyl ether; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)85080-8