3-Hydroxybenzylhydrazine

Base Information

• Chemical Name: 3-Hydroxybenzylhydrazine
• CAS No.: 637-33-2
• Molecular Formula: C7H10N2O
• Molecular Weight: 138.169
• Hs Code.: 2928000090
• UNII: A27K5Q85R2
• DSSTox Substance ID: DTXSID20213099
• Nikkaji Number: J13.151B
• Wikidata: Q27073730
• Metabolomics Workbench ID: 131991
• ChEMBL ID: CHEMBL352205
• Mol file: 637-33-2.mol

Synonyms:3-hydroxybenzylhydrazine;3-hydroxybenzylhydrazine hydrochloride;m-hydroxybenzylhydrazine;NSD 1015;NSD-1015

Chemical Property of 3-Hydroxybenzylhydrazine

Chemical Property:

• Melting Point: 114-115℃
• Boiling Point: 357.7 °C at 760 mmHg
• PKA: 9.89±0.10(Predicted)
• Flash Point: 170.1 °C
• PSA: 58.28000
• Density: 1.184 g/cm³
• LogP: 1.44670
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 138.079312947
• Heavy Atom Count: 10
• Complexity: 97.6

Purity/Quality:

99% ^*data from raw suppliers

3-(hydrazinomethyl)phenol 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)CNN

Technology Process of 3-Hydroxybenzylhydrazine

There total 3 articles about 3-Hydroxybenzylhydrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

meta-hydroxybenzaldehyde (100-83-4) → 3-hydroxybenzylhydrazine (637-33-2)

Guidance literature:

With hydrogen; hydrazine hydrate; palladium on activated charcoal; In isopropyl alcohol;

DOI:10.1021/jm01238a010

Reference yield:

(3-(benzyloxy)benzyl)hydrazine hydrochloride → 3-hydroxybenzylhydrazine (637-33-2)

Guidance literature:

With hydrogenchloride;

DOI:10.1039/P19730000471

Reference yield:

→ 3-hydroxybenzylhydrazine (637-33-2)

Guidance literature:

Aus entspr. Alkoxycarbonylhydrazin;

upstream raw materials:

meta-hydroxybenzaldehyde

Downstream raw materials:

1-(3-Hydroxy-benzyl)-2-isopropyliden-hydrazin

{(R)-4-[(1R,3aS,3bR,4R,5aS,10aS,10bS,12S,12aR)-4,12-Dihydroxy-8-(3-hydroxy-benzyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-7,8-diaza-dicyclopenta[a,h]phenanthren-1-yl]-pentanoylamino}-acetic acid tert-butyl ester

{(R)-4-[(1R,3aS,3bR,4R,5aS,10aS,10bS,12aR)-4-Hydroxy-8-(3-hydroxy-benzyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-7,8-diaza-dicyclopenta[a,h]phenanthren-1-yl]-pentanoylamino}-acetic acid tert-butyl ester

{(R)-4-[(1R,3aS,3bR,5aR,10aS,10bS,12aR)-8-(3-Hydroxy-benzyl)-10a,12a-dimethyl-1,2,3,3a,3b,4,5,5a,6,8,10,10a,10b,11,12,12a-hexadecahydro-7,8-diaza-dicyclopenta[a,h]phenanthren-1-yl]-pentanoylamino}-acetic acid tert-butyl ester