(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

Base Information

Chemical Name:(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide
CAS No.:256393-11-0
Molecular Formula:C₂₄H₃₅NO₅S
Molecular Weight:449.612
Hs Code.:

Synonyms:(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

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Chemical Property of (1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

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Technology Process of (1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

There total 4 articles about (1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 256393-05-2
(1S)-N,N-diisopropyl (2,2-dimethoxy-7,7-dimethylbicyclo[2.2.1]hept-1-yl)methanesulfonamide

: 611-71-2,611-72-3,17199-29-0,90-64-2
MANDELIC ACID

: 256393-11-0
(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

Guidance literature:: With boron trifluoride diethyl etherate; In diethyl ether; at -45 ℃;
DOI:10.1021/ol9910666

Reference yield: 56.0%

: 256393-11-0
(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

Guidance literature:

Reference yield:

: 256393-09-6
(1S,2S,5'R)-N,N-diisopropyl [2-spiro-2'-(5'-phenylmethyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

: 256393-11-0
(1S,2S,5'S)-N,N-diisopropyl [2-spiro-2'-(5'-phenyl-1',3'-dioxolane-4'-one)-7,7-dimethylbicyclo[2.2.1]hept-1-yl]methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: 91 percent / hydrogen chloride / 6 h / Heating

2: 85 percent / PTSA / 84 h / 20 °C

3: 56 percent / BF₃*OEt₂ / diethyl ether / -45 °C

With hydrogenchloride; boron trifluoride diethyl etherate; toluene-4-sulfonic acid; In diethyl ether;
DOI:10.1021/ol9910666