N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

Base Information

Chemical Name:N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide
CAS No.:676557-31-6
Molecular Formula:C₃₅H₂₃F₆N₃O₃
Molecular Weight:647.576
Hs Code.:

Synonyms:N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

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Chemical Property of N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

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Technology Process of N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

There total 3 articles about N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1074-82-4
potassium phtalimide

: 676557-15-6
2-bromomethyl-4-phenyl-quinoline-3-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

: 676557-31-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 2h;
DOI:10.1021/jm034219a

Reference yield:

: 676557-18-9
2-hydroxymethyl-4-phenyl-quinoline-3-carboxylic acid (3,5-bis-trifluoromethyl-benzyl)-methyl-amide

: 676557-31-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / phosphorus tribromide / CH₂Cl₂ / 1 h / 20 °C

2: 81 percent / dimethylformamide / 2 h / 20 °C

With phosphorus tribromide; In dichloromethane; N,N-dimethyl-formamide; 2: Gabriel synthesis;
DOI:10.1021/jm034219a

Reference yield:

: 676557-30-5
N-[3,5-bis(trifluoromethyl)benzyl]-2-[[(t-butyl)dimethylsilyloxy]methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

: 676557-31-6
N-[3,5-bis(trifluoromethyl)benzyl]-2-[(1,3-dioxo-2,3-dihydro-1H-2-isoindolyl)methyl]-N-methyl-4-phenyl-3-quinolinecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1: 76 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1.33 h / 0 - 20 °C

2: 92 percent / phosphorus tribromide / CH₂Cl₂ / 1 h / 20 °C

3: 81 percent / dimethylformamide / 2 h / 20 °C

With tetrabutyl ammonium fluoride; phosphorus tribromide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 3: Gabriel synthesis;
DOI:10.1021/jm034219a