Chemical Property of Ceftibuten
Chemical Property:
- Vapor Pressure:0mmHg at 25°C
- Refractive Index:1.762
- Boiling Point:966.4 °C at 760 mmHg
- PKA:2.99±0.50(Predicted)
- Flash Point:538.3 °C
- PSA：216.46000
- Density:1.75 g/cm3
- LogP:0.86180
- Storage Temp.:2-8°C
- Solubility.:Soluble in aqueous solutions. Also soluble in DMSO
- XLogP3:-0.3
- Hydrogen Bond Donor Count:4
- Hydrogen Bond Acceptor Count:10
- Rotatable Bond Count:6
- Exact Mass:410.03547653
- Heavy Atom Count:27
- Complexity:755
- Purity/Quality:
-
99% *data from raw suppliers
Ceftibuten hydrate ≥98% (HPLC) *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1C=C(N2C(S1)C(C2=O)NC(=O)C(=CCC(=O)O)C3=CSC(=N3)N)C(=O)O
- Isomeric SMILES:C1C=C(N2[C@H](S1)[C@@H](C2=O)NC(=O)/C(=C\CC(=O)O)/C3=CSC(=N3)N)C(=O)O
- Recent ClinicalTrials:P1, DDI & MAD PK and Safety Study of Xeruborbactam Oral Prodrug in Combo With Ceftibuten in Healthy Participants
- Recent EU Clinical Trials:Impact on the intestinal microbiota during antibiotic treatment
-
Description
Ceftibuten is a new, once daily, orally active cephalosporin introduced as a treatment of
Gram-negative bacteria-related urinarylrespiratory tract and gynecological infections.
In vitro studies of 359 strains of Gram-negative bacteria demonstrated that ceftibuten
was superior to cefaclor and as active or slightly more active than cefixime and
cefteram.
-
Uses
anorexic, antidepressant, inhibitor of 5HT, norepinephrine & dopamine uptake
-
Clinical Use
Ceftibuten (Cedax) is a recently introduced, chemicallynovel analog of the oximino cephalosporins in which anolefinic methylene group (C＝CHCH2-) with Z stereochemistryhas replaced the syn oximino (CBNO-) group.This isosteric replacement yields a compound that retainsresistance to hydrolysis catalyzed by many β-lactamases,has enhanced chemical stability, and is orally active. Oralabsorption is rapid and nearly complete. It has the highestoral bioavailability of the third-generation cephalosporins.Ceftibuten is excreted largely unchanged in the urine andhas a half-life of about 2.5 hours. Plasma protein binding ofthis cephalosporin is estimated to be 63%.Ceftibuten possesses excellent potency against mostmembers of the Enterobacteriaceae family, H. influenzae,Neisseria spp., and M. catarrhalis. It is not active against S.aureus or P. aeruginosa and exhibits modest antistreptococcal activity. Ceftibuten is recommended in the managementof community-acquired respiratory tract, urinary tract, andgynecological infections.
