(1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

Base Information

Chemical Name:(1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride
CAS No.:1369998-34-4
Molecular Formula:C₂₀H₂₆N₂*ClH
Molecular Weight:330.901
Hs Code.:

Synonyms:(1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

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Chemical Property of (1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

Chemical Property:

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Technology Process of (1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

There total 4 articles about (1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1369998-47-9
(1R,2R)-1-phenyl-2-(1-piperidinyl)-1-chloropropane hydrochloride

: 62-53-3
aniline

: 1369998-34-4
(1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

Guidance literature:: (1R,2R)-1-phenyl-2-(1-piperidinyl)-1-chloropropane hydrochloride; aniline; In dichloromethane; acetonitrile; at 5 - 20 ℃; Inert atmosphere;

With hydrogenchloride; In isopropyl alcohol; optical yield given as %ee; enantioselective reaction; Inert atmosphere;
DOI:10.1002/chir.21996

Reference yield:

: 111-24-0
1,5-dibromo-pentane

: 1369998-34-4
(1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / water / pH 12 - 13 / Inert atmosphere

1.2: 12 h / Reflux; Inert atmosphere

1.3: pH 2 - 3 / Inert atmosphere

2.1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 2 h / 45 - 50 °C / Inert atmosphere

3.1: dichloromethane; acetonitrile / 5 - 20 °C / Inert atmosphere

3.2: Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; chloroform; water; acetonitrile;
DOI:10.1002/chir.21996

Reference yield:

: (1S,2R)-(+)-1-phenyl-2-(1-piperidinyl)-1-propanol hydrochloride

: 1369998-34-4
(1R,2R)-(-)-1-phenyl-1-phenylamino-2-(1-piperidinyl)propane hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride; N,N-dimethyl-formamide / chloroform / 2 h / 45 - 50 °C / Inert atmosphere

2.1: dichloromethane; acetonitrile / 5 - 20 °C / Inert atmosphere

2.2: Inert atmosphere

With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; chloroform; acetonitrile;
DOI:10.1002/chir.21996