3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

Base Information

Chemical Name:3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide
CAS No.:1377997-28-8
Molecular Formula:C₂₇H₂₈ClN₅O₂
Molecular Weight:490.005
Hs Code.:

Synonyms:3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

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Chemical Property of 3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

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Technology Process of 3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

There total 4 articles about 3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 4-(3-bromo-2-cyanophenoxy)-3-chloro-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

: 194865-89-9
4-(tributylstannanyl)pyridazine

: 1377997-28-8
3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; lithium chloride; In toluene; at 90 ℃; for 12h;
DOI:10.1021/ml400494b

Reference yield:

: 4-(3-bromo-2-cyanophenoxy)-3-chlorobenzoic acid

: 1377997-28-8
3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.5 h / 20 °C

1.2: 3 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / toluene / 12 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; In dichloromethane; toluene;
DOI:10.1021/ml400494b

Reference yield:

: 3964-58-7
3-chloro-4-hydroxybenzoic acid

: 1377997-28-8
3-chloro-4-(2-cyano-3-(pyridazin-4-yl)phenoxy)-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / dimethyl sulfoxide / 3 h / 140 °C

2.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 0.5 h / 20 °C

2.2: 3 h / 20 °C

3.1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / toluene / 12 h / 90 °C

With bis-triphenylphosphine-palladium(II) chloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium chloride; In dichloromethane; dimethyl sulfoxide; toluene;
DOI:10.1021/ml400494b