(R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Base Information

Chemical Name:(R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide
CAS No.:1062131-41-2
Molecular Formula:C₃₃H₄₁N₉O₃
Molecular Weight:611.747
Hs Code.:

Synonyms:(R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

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Chemical Property of (R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

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Technology Process of (R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

There total 10 articles about (R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.88%

: 1062131-08-1
(R)-4-tert-butyl-N-(1-(7-cyano-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)benzamide

: 1062131-41-2
(R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Guidance literature:: With ammonia; hydrogen; nickel; In tetrahydrofuran; methanol; at 20 ℃; for 1.5h;

Reference yield:

: 254114-39-1
6,8-Bis(methylsulfanyl)imidazo[2,1-f][1,2,4]triazine

: 1062131-41-2
(R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / chloroform / 1 h / Heating / reflux

2: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / DMA / 0.25 h / 150 °C / sealed vial; microwave irradiation

3: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

4: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

5: 1-methyl-pyrrolidin-2-one / 16 h / 150 °C

6: ammonia; hydrogen / nickel / tetrahydrofuran; methanol / 1.5 h / 20 °C

With N-Bromosuccinimide; potassium tert-butylate; ammonia; hydrogen; 3-chloro-benzenecarboperoxoic acid; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; DMA; chloroform;

Reference yield:

: 1062135-87-8
7-bromo-2,4-bis(methylthio)imidazo[2,1-f][1,2,4]triazine

: 1062131-41-2
(R)-N-(1-(7-(aminomethyl)-4-(4-(morpholine-4-carbonyl)phenylamino)imidazo[1,2-f][1,2,4]triazin-2-yl)piperidin-3-yl)-4-tert-butylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: zinc / 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / DMA / 0.25 h / 150 °C / sealed vial; microwave irradiation

2: potassium tert-butylate / tetrahydrofuran / 1.08 h / 20 °C

3: 3-chloro-benzenecarboperoxoic acid / tetrahydrofuran / 3 h / 20 °C

4: 1-methyl-pyrrolidin-2-one / 16 h / 150 °C

5: ammonia; hydrogen / nickel / tetrahydrofuran; methanol / 1.5 h / 20 °C

With potassium tert-butylate; ammonia; hydrogen; 3-chloro-benzenecarboperoxoic acid; zinc; 1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; nickel; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; DMA;