2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

Base Information

Chemical Name:2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine
CAS No.:259874-89-0
Molecular Formula:C₂₃H₃₃NO₂SSi
Molecular Weight:415.672
Hs Code.:

Synonyms:2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

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Chemical Property of 2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

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Technology Process of 2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

There total 8 articles about 2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 259874-75-4
N-[(Z)-6-dimethyl-(1-phenylethyl)silyl-5-hexenyl]-p-toluenesulfonamide

: 81097-32-7
N-hex-5-enyl(4-methylphenyl)sulfonamide

: 259874-89-0
2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

Guidance literature:: With titanium tetrachloride; In chloroform; at 20 ℃; for 3.5h;
DOI:10.1021/ol991341o

Reference yield:

: (Z)-6-[Dimethyl-(1-phenyl-ethyl)-silanyl]-hex-5-enal

: 259874-89-0
2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

Guidance literature:: Multi-step reaction with 4 steps

1: NH₂OH*HCl; Na₂CO₃ / H₂O / 20 °C

2: LAH / diethyl ether; diisopropyl ether / 55 °C

3: Et₃N / CH₂Cl₂

4: 78 percent / TiCl₄ / CHCl₃ / 3.5 h / 20 °C

With lithium aluminium tetrahydride; hydroxylamine hydrochloride; titanium tetrachloride; sodium carbonate; triethylamine; In diethyl ether; dichloromethane; chloroform; di-isopropyl ether; water; 1: Substitution / 2: Reduction / 3: Acylation / 4: Cyclization;
DOI:10.1021/ol991341o

Reference yield:

: (Z)-6-[Dimethyl-(1-phenyl-ethyl)-silanyl]-hex-5-enylamine

: 259874-89-0
2-[dimethyl(1-phenylethyl)silyl]methyl-1-p-toluenesulfonylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂

2: 78 percent / TiCl₄ / CHCl₃ / 3.5 h / 20 °C

With titanium tetrachloride; triethylamine; In dichloromethane; chloroform; 1: Acylation / 2: Cyclization;
DOI:10.1021/ol991341o