4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

Base Information

Chemical Name:4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide
CAS No.:1363401-51-7
Molecular Formula:C₂₆H₁₉F₄N₃O₂
Molecular Weight:481.449
Hs Code.:

Synonyms:4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

Suppliers and Price of 4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

There total 2 articles about 4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 849833-86-9
(3-fluoro-4-(methylcarbamoyl)phenyl)boronic acid

: 1363401-52-8
4-(5-bromo-3,3-dimethyl-2-oxoindolin-1-yl)-2-(trifluoromethyl)benzonitrile

: 1363401-51-7
4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; cesium fluoride; In water; N,N-dimethyl-formamide; at 110 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.bmcl.2012.01.116

Reference yield:

: 120902-45-6
5-bromo-3,3-dimethyl-1,3-dihydro-2H-indol-2-one

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1363401-51-7
4-(1-(4-cyano-3-(trifluoromethyl)phenyl)-3,3-dimethyl-2-oxoindolin-5-yl)-2-fluoro-N-methylbenzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium tert-butylate / dimethyl sulfoxide / 25 h

2: bis-triphenylphosphine-palladium(II) chloride; cesium fluoride / water; N,N-dimethyl-formamide / 0.25 h / 110 °C / Microwave irradiation

With bis-triphenylphosphine-palladium(II) chloride; potassium tert-butylate; cesium fluoride; In water; dimethyl sulfoxide; N,N-dimethyl-formamide; 2: Suzuki coupling;
DOI:10.1016/j.bmcl.2012.01.116