((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

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Chemical Name:((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester
CAS No.:200949-22-0
Molecular Formula:C₄₃H₄₅N₅O₇
Molecular Weight:743.86
Hs Code.:

((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Synonyms:((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

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Chemical Property of ((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

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Technology Process of ((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

There total 1 articles about ((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35737-15-6
Fmoc-Trp-OH

: 83595-75-9
H-Ala-Val-Gly-OBzl trifluoroacetic acid salt

: 200949-22-0
((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In N,N-dimethyl-formamide; for 1h; Yield given; Ambient temperature;
DOI:10.1016/S0223-5234(99)80063-4

Reference yield: 97.0%

: 200949-22-0
((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

: 771441-12-4
((S)-2-{(S)-2-[(S)-2-Amino-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

Guidance literature:: With diethylamine; In N,N-dimethyl-formamide; for 0.5h; Ambient temperature;
DOI:10.1016/S0223-5234(99)80063-4

Reference yield:

: 200949-22-0
((S)-2-{(S)-2-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionylamino]-propionylamino}-3-methyl-butyrylamino)-acetic acid benzyl ester

: H-D-Phe-Gln-Trp-Ala-Val-Gly-His-LeuΨ(CH2O)Nle-NH2

Guidance literature:: Multi-step reaction with 7 steps

1: 97 percent / Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

2: 85 percent / BOP, N-methylmorpholine / dimethylformamide / 2 h / Ambient temperature

3: 91 percent / Et₂NH / dimethylformamide / 0.5 h / Ambient temperature

4: 89 percent / BOP, N-methylmorpholine / dimethylformamide / 1 h / Ambient temperature

5: 96 percent / H₂ / 10percent Pd/C / dimethylformamide; ethanol / 2 h / Ambient temperature

6: 71 percent / BOP, N-methylmorpholine / dimethylformamide / 2 h

7: 80 percent / 2-methylindole, CF₃COOH / Ambient temperature

With 4-methyl-morpholine; 2-methyl-1H-indole; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; diethylamine; trifluoroacetic acid; palladium on activated charcoal; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/S0223-5234(99)80063-4