(S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

Base Information

Chemical Name:(S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide
CAS No.:1112130-86-5
Molecular Formula:C₂₅H₃₄FNO₂SSi
Molecular Weight:459.7
Hs Code.:

Synonyms:(S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

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Chemical Property of (S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

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Technology Process of (S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

There total 6 articles about (S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1112130-96-7
(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenal

: 343338-28-3
(S)-2-methylpropane-2-sulfinamide

: 1112130-86-5
(S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

Guidance literature:: With titanium(IV) tetraethanolate; In tetrahydrofuran; for 1.25h; Reflux;
DOI:10.1039/c0ob00773k

Reference yield:

: 918828-69-0
(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-penten-1-ol

: 1112130-86-5
(S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 6 h / Reflux

2: titanium(IV) tetraethanolate / tetrahydrofuran / 1.25 h / Reflux

With titanium(IV) tetraethanolate; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; ethyl acetate;
DOI:10.1039/c0ob00773k

Reference yield:

: 112897-03-7
3-(tert-butyldiphenylsilyloxy)-1-propanal

: 1112130-86-5
(S)-N-(Z)-5-([tert-butyl(diphenyl)silyl]oxy)-2-fluoro-2-pentenylidene-2-methyl-2-propanesulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: diethylzinc / hexane; dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.58 h / 0 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 6 h / Reflux

4.1: titanium(IV) tetraethanolate / tetrahydrofuran / 1.25 h / Reflux

With titanium(IV) tetraethanolate; lithium aluminium tetrahydride; diethylzinc; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; hexane; dichloromethane; ethyl acetate;
DOI:10.1039/c0ob00773k