3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester

Base Information

• Chemical Name: 3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester
• CAS No.: 261724-04-3
• Molecular Formula: C₃₄H₄₆N₆O₁₀
• Molecular Weight: 698.773
• Mol file: 261724-04-3.mol

Synonyms:3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester

Chemical Property of 3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester

There total 1 articles about 3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(tert-butyloxycarbonyl)-(S)-alanylglycine (28782-78-7) + benzyl 3,5-diaminobenzoate (261724-01-0) → 3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester (261724-04-3)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃;

DOI:10.1016/S0968-0896(99)00226-6

Reference yield:

3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester (261724-04-3) → 3,5-Bis-(2-{(S)-2-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-propionylamino}-acetylamino)-benzoic acid (261724-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: TFA

2: 70 percent / DCC; HOBt; DIEA / CH₂Cl₂ / 17 h / 20 °C

3: 97 percent / H₂ / 10 percent Pd/C / ethanol / 1.5 h / 20 °C

With hydrogen; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In ethanol; dichloromethane; 1: Hydrolysis / 2: Condensation / 3: Hydrogenolysis;

DOI:10.1016/S0968-0896(99)00226-6

Reference yield:

3,5-bis-[2-(2-tert-butoxycarbonylamino-propionylamino)-acetylamino]-benzoic acid benzyl ester (261724-04-3) → 3,5-Bis-(2-{(S)-2-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-propionylamino}-acetylamino)-benzoic acid benzyl ester (261724-06-5)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA

2: 70 percent / DCC; HOBt; DIEA / CH₂Cl₂ / 17 h / 20 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In dichloromethane; 1: Hydrolysis / 2: Condensation;

DOI:10.1016/S0968-0896(99)00226-6

upstream raw materials:

N-(tert-butyloxycarbonyl)-(S)-alanylglycine

benzyl 3,5-diaminobenzoate

Downstream raw materials:

3,5-Bis-(2-{(S)-2-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-propionylamino}-acetylamino)-benzoic acid

3,5-Bis-(2-{(S)-2-[2-((2R,3S,4R,5S,6R)-3,4,5-triacetoxy-6-acetoxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-propionylamino}-acetylamino)-benzoic acid benzyl ester