N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Base Information

Chemical Name:N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide
CAS No.:1426132-74-2
Molecular Formula:C₂₂H₁₉F₂N₅O₃
Molecular Weight:439.421
Hs Code.:

Synonyms:N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Chemical Property of N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

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Technology Process of N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

There total 14 articles about N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426135-66-1
5,5-difluorotetrahydro-2H-pyran-2-carboxylic acid

: 1426135-65-0
N-(5-(N'-hydroxycarbamimidoyl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426132-74-2
N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 110 ℃; for 0.5h;

Reference yield:

: 1426135-64-9
N-(5-cyano-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

: 1426132-74-2
N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / water; ethanol / 4 h / 20 - 50 °C

2: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 110 °C

With hydroxylamine; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 756524-92-2
((2-(allyloxy)pent-4-enyloxy)methyl)benzene

: 1426132-74-2
N-(5-(5-(5,5-difluorotetrahydro-2H-pyran-2-yl)-1,2,4-oxadiazol-3-yl)-2-methylphenyl)imidazo[1,2-a]pyridine-3-carboxamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: Grubbs catalyst first generation / toluene / 2 h / 50 °C / Inert atmosphere

2.1: sodium hydroxide / toluene; isopropyl alcohol / 120 °C

3.1: dimethylsulfide borane complex / tetrahydrofuran / -78 - 20 °C

4.1: dihydrogen peroxide / tetrahydrofuran / 2 h / 0 - 20 °C

5.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

5.2: -78 - 0 °C

6.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / toluene / -78 - 20 °C

7.1: hydrogen; 10 wt% Pd(OH)2 on carbon / methanol / 2 h

8.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1 h / -78 °C

8.2: -78 - 0 °C

9.1: 2-methyl-but-2-ene; sodium dihydrogenphosphate; sodium chlorite / water; tert-butyl alcohol / 2 h / 0 - 20 °C

10.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 0.5 h / 110 °C

With Grubbs catalyst first generation; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; dimethylsulfide borane complex; 10 wt% Pd(OH)2 on carbon; hydrogen; dihydrogen peroxide; dimethyl sulfoxide; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; toluene; tert-butyl alcohol;