4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Base Information

Chemical Name:4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide
CAS No.:1445790-55-5
Molecular Formula:C₁₈H₁₆F₄N₂O₄S
Molecular Weight:432.396
Hs Code.:

Synonyms:4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Suppliers and Price of 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 5 raw suppliers

Chemical Property of 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

There total 6 articles about 4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 4-fluoro-3-((4-hydroxypiperidin-1-yl)sulfonyl)benzoic acid

: 163733-96-8
3,4,5-trifluoro aniline

: 1445790-55-5
4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Guidance literature:: 4-fluoro-3-((4-hydroxypiperidin-1-yl)sulfonyl)benzoic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25 ℃; for 0.5h;

3,4,5-trifluoro aniline; In N,N-dimethyl-formamide; at 25 ℃; for 12h;
DOI:10.1021/acsmedchemlett.0c00606

Reference yield:

: 5382-16-1
4-HYDROXYPIPERIDINE

: 1445796-56-4
2-fluoro-5-(3,4,5-trifluorophenylcarbamoyl)benzene-1-sulfonyl chloride

: 1445790-55-5
4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Guidance literature:: With triethylamine; In acetonitrile; at 20 ℃; for 3h;

Reference yield:

: 2267-40-5
3-chlorosulfonyl-4-fluoro-benzoic acid

: 1445790-55-5
4-fluoranyl-3-(4-oxidanylpiperidin-1-yl)sulfonyl-N-[3,4,5-tris(fluoranyl)phenyl]benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: thionyl chloride / Reflux

2: toluene / 2 h / Reflux

3: triethylamine / acetonitrile / 3 h / 20 °C

With thionyl chloride; triethylamine; In toluene; acetonitrile;